2024年12月25日 · FXR2 (FMR1 Autosomal Homolog 2) is a Protein Coding gene. Diseases associated with FXR2 include Fragile X Syndrome and X-Linked Hereditary Ataxia. Among its related pathways are VEGFA-VEGFR2 signaling and Translational Control. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and identical protein binding.

The fragile X-related (FXR) family proteins FMRP, FXR1, and FXR2 are RNA binding proteins that play a critical role in RNA metabolism, neuronal plasticity, and muscle development. These proteins share significant homology in their protein domains, which are functionally and structurally similar to e …

FXR1P and FXR2P KH2 domains bind G-quadruplex and kissing complex RNA with the same affinity as the FMRP KH2 domain. The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits.

该基因编码的蛋白是一种含有两个 KH 结构域和一个 RCG 盒的 RNA 结合蛋白，与 FMRP 和 FXR1 相似。 它与多聚核糖体结合，主要与 60S 大核糖体亚基结合。 这种编码的蛋白质可能与 FMRP 和 FXR1 自我结合或相互作用。 它可能在脆性 X 认知障碍综合征的发展中起作用。 [RefSeq 提供，2008 年 7 月] The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1.

2015年6月16日 · FMRP and FXR2P additively promote the maturation of new neurons by regulating a common target, the AMPA receptor GluA1, but they do so via distinct mechanisms: FXR2P binds and stabilizes GluA1 mRNA and enhances subsequent protein expression, whereas FMRP promotes GluA1 membrane delivery.

Fragile X mental retardation syndrome-related protein 2 is a protein that in humans is encoded by the FXR2 gene. [5] [6] [7]

法尼醇X受体（Farnesoid X Receptor，FXR）是核受体（nuclear receptor，NR）超家族的成员，属于亚家族（Subfamily）1、组（Group）H、成员（Member）4，因此可称为NR1H4，在人类由核受体基因NR1H4编码。

2019年10月14日 · We’d like to re-visit one of the bikes we featured previously, a beautiful purple 1999 FXR2. From 1982 to 1995, the Harley-Davidson FXR paved the way for the Dyna, and, more recently, the sportier Softail models. In fact, the 2020 Low Rider S can trace its lineage back to the FXR, right down to its steep 28 degree front rake.

2011年6月9日 · Here, we show that the RNA-binding protein FXR2 specifically regulates DG neurogenesis by reducing the stability of Noggin mRNA. FXR2 deficiency leads to increased Noggin expression and subsequently reduced BMP signaling, which results in increased proliferation and altered fate specification of neural stem/progenitor cells in DG.

2011年6月6日 · Here we show that the RNA-binding protein FXR2 specifically regulates DG neurogenesis by reducing the stability of Noggin mRNA. FXR2 deficiency leads to increased Noggin expression and subsequently reduced BMP signaling, which results in increased proliferation and altered fate specification of neural stem/progenitor cells in DG.