2025年1月18日 · We developed the FORCE TM platform to overcome limitations of oligonucleotide delivery to muscle and enable their applicability to neuromuscular disorders. The platform consists of an...

2024年3月1日 · Transferrin receptor 1 (TfR1) is an especially popular target for this molecular Trojan horse strategy. TfR1 forms a homodimer consisting of two subunits which bind to holo-transferrin (holo-Tf) and thus plays an important role in iron transport into cells and across the BBB (Fig. 1) [12].

2024年8月14日 · Here, we engineered a human transferrin receptor 1 (TfR1) binding molecule, the oligonucleotide transport vehicle (OTV), to transport a tool ASO across the BBB in human TfR knockin (TfR mu/hu KI) mice and nonhuman primates.

2025年2月16日 · Transferrin receptor-1 (TfR1) transcytosis-mediated delivery of therapeutic monoclonal antibodies across the blood-brain barrier (BBB) is a promising concept in drug development for CNS disorders. We sought to investigate brain delivery and efficacy of Aducanumab (Adu), an anti-Aβ antibody, when fused to a mouse TfR1-binding Fab fragment as ...

2024年10月23日 · 这一研究于2024年9月25日发表在Nature上，TransTAC代表了一类有前景的新型双功能抗体家族，可用于精确调控膜蛋白和靶向癌症治疗。 现有研究证实，TFR1在许多肿瘤细胞中高表达，是潜在的肿瘤标志物，且针对TFR1进行治疗可以有效地抑制肿瘤生长和转移。 此外，TFR1还与其它疾病如贫血、铁代谢障碍性疾病等有关。 因此，以TFR1为靶点的治疗策略来靶向调节细胞内铁水平，可以在相关疾病的临床应用中发挥重要作用。 1. 什么是TFR1？ 2. TFR1 …

2021年3月17日 · The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type II transmembrane glycoprotein that binds transferrin (Tf) and performs a critical role in cellular iron uptake through the interaction with iron-bound Tf.

2023年9月12日 · At this year’s annual meeting of the American Society of Gene & Cell Therapy, Dyne Therapeutics described a monovalent Fab antibody variable region fragment with high affinity for TfR1 that...

2022年11月8日 · TfR1 is a 97 kDa type II membrane protein expressed as a homodimer (40, 41). The TfR1 binds to iron-laden transferrin and translocates it across brain ECs. Using an anti-TfR1 antibody to translocate a cargo across the BBB has been …

2021年12月13日 · Her team attached various siRNA payloads to an antigen-binding fragment (Fab) that engaged the HIV-1 envelope protein. As a linker they used protamine, a protein that binds and packages DNA....

2013年6月13日 · In this work, the potential of 8D3 to carry molecules across the BBB was investigated. This antibody (either unlabeled or FITC-labeled) was intravenously administered to ICR-CD1 mice.