2003年12月19日 · β-Ketoacyl-acyl carrier protein (ACP) synthase III (KAS III, also called acetoacetyl-ACP synthase) encoded by the fabH gene is thought to catalyze the first elongation reaction (Claisen condensation) of type II fatty acid synthesis in bacteria and plant plastids.

2001年3月16日 · β-Ketoacyl-acyl carrier protein synthase III (FabH) is a condensing enzyme that plays central roles in fatty acid biosynthesis. Three-dimensional structures of E. coli FabH in the presence and absence of ligands have been refined to 1.46 Å resolution. The structures of improved accuracy revealed detailed interactions involved in ligand binding.

其中β-酮脂酰-ACP合成酶Ⅲ(KAS Ⅲ，FabH)控制着细菌脂肪酸生物合成的起始步骤，普遍存在于病原体中且在人体中无其同源蛋白，成为新型抗菌药物靶标研究的热点。抑制FabH酶活性的小分子抑制剂有望成为对细菌具选择性而对人体无毒的广谱抗菌药。

2000年1月15日 · Two genes that were predicted to encode homologs of the β-ketoacyl-acyl carrier protein synthase III of Escherichia coli (eFabH) were identified in the Bacillus subtilis genome. Their protein products were expressed, purified, and biochemically characterized.

2003年12月19日 · beta-Ketoacyl-acyl carrier protein (ACP) synthase III (KAS III, also called acetoacetyl-ACP synthase) encoded by the fabH gene is thought to catalyze the first elongation reaction (Claisen condensation) of type II fatty acid synthesis in bacteria and plant plastids.

FabH, β-ketoacyl-ACP synthase III, is a particularly attractive target, since it is central to the initiation of fatty acid biosynthesis and is highly conserved among Gram-positive and -negative bacteria.

Fatty acid biosynthesis is essential for bacterial survival. Of these promising targets, β-ketoacyl-acyl carrier protein (ACP) synthase III (FabH) is the most attractive target. FabH would trigger the initiation of fatty acid biosynthesis and it is highly conserved among Gram-positive and …

1998年3月9日 · We report herein the purification and characterization of the thiolactomycin-sensitive S. glaucescens FabH. Our results showed that Streptomyces FabH is able to utilize different acyl-CoA substrates, with a significantly lower Km for the four-carbon acyl-CoA substrates butyryl-CoA and isobutyryl-CoA than for acetyl-CoA.

FabH酶催化脂肪酸生物合成的第一步，这对于细菌的生存至关重要。 因此，FabH已被确定为开发新型抗菌剂的有吸引力的靶标。 我们在这里提出了一种有前景的，具有低毒性和强效FabH抑制作用的吡唑-苯并咪唑酰胺新系列的发现。

2016年5月16日 · 其中β2酮脂酰2ACP合成酶Ⅲ (KASⅢ,FabH)控制着细菌脂肪酸生物合成的起. 始步骤,普遍存在于病原体中且在人体中无其同源蛋白,成为新型抗菌药物靶标研究的热点。 抑制FabH酶. 活性的小分子抑制剂有望成为对细菌具选择性而对人体无毒的广谱抗菌药。 本文对脂肪酸的生物合成、 FabH的相关结构研究以及目前FabH抑制剂的研究进展进行了综述。 paper,fattyacidbiosynthesis,recentadvancesintheresearchofFabHaswellasrelatedinhibitorsarereviewed. …