2022年8月23日 · Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs. Most people with factor V Leiden never develop abnormal clots.

Factor V Leiden is an inherited blood clotting disorder that raises your risk of deep vein thrombosis or a pulmonary embolism. A mutation in your F5 gene causes this disorder, which follows an autosomal dominant inheritance pattern. Most people with this disorder never develop a blood clot. But if you do, prompt treatment can manage your condition.

Coagulation factor V (Factor V), also less commonly known as proaccelerin or labile factor, is a protein involved in coagulation, encoded, in humans, by F5 gene. [5] In contrast to most other coagulation factors, it is not enzymatically active but functions as a cofactor. [5]

Factor V Leiden is an inherited condition caused by a specific genetic mutation in the factor V gene. This gene is responsible for producing a protein called factor V, which plays a crucial role in the clotting system. The mutation in the factor V gene leads to the production of an abnormal form of factor V, known as factor V Leiden.

2015年5月18日 · Factor V Leiden is a point mutation of factor V, resulting in an elimination of the cleavage site in factor V and factor Va. This genetic defect leads to an increased risk of thrombosis, especially in homozygous or pseudo-homozygous factor V Leiden mutations.

2024年10月13日 · Factor V Leiden (FVL) is a change in your genes that affects one of the clotting factors in your blood and keeps your body's blood -clotting process from working right. It can cause a disorder...

2023年7月17日 · Factor V is a glycoprotein that contributes to both procoagulant and anticoagulant function. This function is determined by which enzymes are present that can modify factor V. Factor V gets modified by activated factor X, thrombin, and activated protein C (aPC). Factor V plays a part in the common pathway of the coagulation cascade.

Factor V Leiden is the name of a specific gene mutation that results in thrombophilia, which is an increased tendency to form abnormal blood clots that can block blood vessels. People with factor V Leiden thrombophilia have a higher than average risk of developing a type of blood clot called a deep venous thrombosis (DVT).

2003年4月22日 · Factor V is a protein in the blood that is required for normal clotting to occur in response to injury. To understand how factor V works, it is important to understand the basics of blood coagulation (see box). Throughout the course of a normal day, the blood vessels sustain many nicks and scrapes on the inside that we cannot see.

A factor V test is a blood test that checks for a deficiency in a protein known as factor V. Factor V is a protein that helps your blood to clot. Having too little factor V can cause a rare bleeding disorder.