[18 F]FAPI-74 PET is a promising novel diagnostic modality for various tumors, especially for precise staging before treatment, including characterization of tumor lesions before surgery. Moreover, 18 F-labeled FAPI ligand might serve a higher demand in clinical care in the future.

What is FAPI-74 and how does it work? FAPI-74 is a radioactive diagnostic agent used in Positron Emission Tomography (PET) imaging. It targets Fibroblast Activation Protein (FAP), which is found in high numbers in certain cancer cells and cancer-associated fibroblasts.

Jan 3, 2023 · Gallium 68 (68 Ga)–labeled fibroblast activation protein (FAP) inhibitor (FAPI) PET is based on the molecular targeting of the FAP, which is known to be highly expressed in the major cell population in tumor stroma, termed cancer-associated fibroblasts.

Aug 21, 2021 · Owing to an excellent performance in PET imaging, FAPI-74 can be regarded as a promising precursor for [18 F]AlF-based FAP-imaging. Keywords: 18F-AlF-FAPI-74; Fibroblast activating protein; Positron Emission Tomography.

Jun 1, 2023 · The 18F-labeled fibroblast activation protein inhibitor (FAPI) [18F]FAPI-74 has the benefit of a higher synthetic yield and better image resolution than 68Ga-labeled FAPI. We preliminarily evaluated the diagnostic performance of [18F]FAPI-74 PET in patients with various histopathologically confirmed cancers or suspected malignancies.

Jan 2, 2024 · Fibroblast activation protein is overexpressed in the stroma of several cancer types. 18 F-fibroblast activation protein inhibitor (FAPI)-74 is a PET tracer with high selectivity for fibroblast activation protein and has shown high accumulation in human tumors in clinical studies.

In Q1 of 2023, [18 F]FAPI-74 will be entering Phase 2 clinical study in patients with Gastrointestinal Cancers, which include hepatocellular carcinoma, cholangiocarcinoma, gastric, pancreatic and colorectal cancer (NCT05641896).

Jun 1, 2024 · [18F]FAPI-74 is a fluorine-18 labelled FAPI product with promising characteristics for detection of neoplastic diseases on PET. Methods: [18F]FAPI-74 is in a Phase 2 clinical study in the United States for diagnosis of gastrointestinal (GI) cancers.

Jun 26, 2020 · Here, we describe the in vivo evaluation of 18 F-FAPI-74 and a proof of mechanism for 68 Ga-FAPI-74 labeled at ambient temperature. Methods: In 10 patients with lung cancer, PET scans were acquired at 10 min, 1 h, and 3 …

[18F]FAPI-74 is a new tracer-a substance that is injected into a person s body before an imaging scan. Researchers believe that [18F]FAPI-74 may be able to highlight FAP enzymes more effectively than approved tracers.