2023年1月3日 · Fibroblast activation protein (FAP) inhibitor (FAPI) used for PET imaging is a strategy that targets the cell population in the tumor surrounding stroma, termed cancer-associated fibroblasts.

Several radiolabeled FAP inhibitors (FAPI) have been developed for molecular imaging and potential theranostic applications. Preliminary data on FAPI PET/CT remains encouraging, with extensive multi-disciplinary clinical research currently underway.

2024年11月6日 · FAPI PET/CT scans are a cutting-edge diagnostic tool that significantly improves cancer detection and staging accuracy. Unlike traditional PET/CT scans that rely on glucose-based tracers, FAPI scans target fibroblast activation proteins, which are …

FAPI-PET appears promising, especially in imaging cancers unsuitable for [¹⁸F]FDG imaging, particularly primary lesions and distant metastases. However, high-level evidence is needed to define its role, specifically to identify cancer types, non-oncological diseases, and clinical settings …

2024年11月13日 · The discovery of fibroblast activation protein inhibitor positron emission tomography (FAPI-PET) has paved the way for a new class of PET tracers that target the tumor...

FAPI demonstrated more lesions and yielded much higher tumor-to-background ratios than 2- [18F]FDG. Preliminary experiences with FAPI PET in breast cancer showed some advantages than the current available 2- [18F]FDG, although prospective trials are needed to further evaluate its diagnostic utility in clinical practice.

2025年1月22日 · The standard techniques currently employed that have proven robust include CT, MRI, and more recently, the 18F-FDG PET/CT scan. FAPI PET CT scan with its latest upgrades holds great potential and eliminates the issues with a few previous investigations.

We present first evidence of diagnostic and therapeutic potential of FAPI ligands in head and neck cancer. Larger studies with histopathological correlation are required to validate our findings.

2025年2月5日 · FAPI PET scan improves the diagnosis and staging of gastric carcinoma, highlighting its advantages over FDG PET/CT and its role in imaging gastric cancer.

2024年5月1日 · This expedited systematic review aims to provide the first overview of the different Fibroblast activation protein inhibitor (FAPI) PET scan procedures in the literature and discuss how to efficiently obtain optimal FAPI PET images based on the best available evidence.