2021年10月21日 · Fatty acid synthase (FASN) is a key enzyme in the endogenous lipogenesis pathway that primarily catalyzes the synthesis of the long-chain saturated FA palmitate from...

2019年11月1日 · Fatty acid synthase (FASN) is a multienzyme protein that catalyzes the synthesis of fatty acids (mainly the long-chain saturated fatty acid palmitate) from acetyl-CoA …

FASN, an essential cytosolic enzyme in DNL pathway, catalyzes the biosynthesis of saturated fatty acids from acetyl-CoA (AcCoA) and malonyl coenzyme A (malonyl-CoA) (26). Recently, …

Carboxylation of acetyl-CoA to malonyl-CoA is catalyzed by acetyl-CoA carboxylase (ACC). FASN condenses one acetyl-CoA and seven malonyl-CoA into palmitate which can be then modified …

2024年1月25日 · Using NADPH as a reduction cofactor, FASN catalyzes the synthesis of acetyl-CoA and malonyl-CoA palmitate and then synthesizes complex fatty acid metabolites.

2023年8月29日 · Fatty acid synthase (FASN) maintains de novo lipogenesis (DNL) to support rapid growth in most proliferating cancer cells. Lipogenic acetyl-coenzyme A (CoA) is primarily …

2008年7月28日 · 在哺乳动物中,脂肪酸合成酶在脂肪酸合成中起着至关重要的作用.它含有7个活性位点,在还原型辅酶Ⅱ的存在下.FASN负责乙酰辅酶A (acetyl-CoA)和丙二酰辅酶A (malonyl …

脂肪酸合成酶是脂肪合成的关键酶,并且在腹脂肪组织重变异及相关性状变异中起着重要作用。 综述了FASN及其基因在生命活动中的地位、作用、定位、结构及FASN基因的遗传变异与生产 …

Its main function is to catalyze the synthesis of palmitate (C16:0, a long-chain saturated fatty acid) from acetyl-CoA and malonyl-CoA, in the presence of NADPH.

2016年7月5日 · Fatty acid synthesis involves the creation of fatty acids from acetyl-coenzyme A (CoA) and malonyl-CoA precursors through the catalytic action of fatty acid synthase (FASN). …