2021年9月23日 · In this Review, we summarize more than 20 years of genetic studies that have characterized the molecules and mechanisms that control body weight, specifically focusing on overall obesity and...

The thrifty gene hypothesis postulates that due to dietary scarcity during human evolution people are prone to obesity. Their ability to take advantage of rare periods of abundance by storing energy as fat would be advantageous during times of varying food availability, and individuals with greater adipose reserves would more likely survive famine.

Fat mass and obesity-associated protein, also known as alpha-ketoglutarate-dependent dioxygenase FTO, is an enzyme that in humans is encoded by the FTO gene located on chromosome 16. As one homolog in the AlkB family proteins, it is the first messenger RNA (mRNA) demethylase that has been identified. [ 5 ]

2025年2月21日 · Is There a “Fat Gene?” There’s one gene that’s getting a lot of attention, called FTO. Scientists found that people with certain differences in this gene have a 20% to 30% higher chance of ...

2014年3月14日 · Now an international team of scientists has discovered that the obesity-associated elements within FTO interact with IRX3, a distant gene on the genome that appears to be the functional obesity gene. The FTO gene itself appears to have only a peripheral effect on obesity, researchers report in the March 12 online of Nature .

The Fat mass and obesity associated (FTO) gene is a newly identified genetic factor for obesity. However, the exact molecular mechanisms responsible for the effect of FTO on obesity remain largely unknown. Recent studies from genome-wide associated studies reveal that genetic variants in the FTO gen …

2024年6月27日 · The most well-known “fat gene,” FTO, explains less than 1 percent of the BMI difference. FTO codes for a brain protein influencing appetite, but its effect results in only a minor difference in calorie intake, around a few hundred extra calories per year.

4 天之前 · Gene-discovery research has followed suit, moving GWASs beyond BMI and obesity as the primary traits and disease outcomes. GWASs have been performed for more refined phenotypes, such as body fat percentage, fat-free mass, visceral and subcutaneous fat, and circulating leptin levels . These studies identified genetic loci that were not found in ...

5 天之前 · UD researchers discover that differences in gene expression in fat could be the key to targeted obesity treatment. According to the CDC, up to 40% of Americans are obese, increasing their risk of high blood pressure, diabetes, stroke, heart disease, and certain cancers. Researchers at the Universit

Monogenic obesity is caused by variants of single genes while polygenic obesity includes several genes with the involvement of members of gene families. New advances in genetic testing have led to the identification of obesity-related genes.