Jan 24, 2021 · Fatty acid transport 1 (FATP1) is an evolutionarily conserved protein that localizes to the plasma membrane to enhance the transportation of fatty acids (FAs). In line with this function, FATP1 is involved in the metabolism of FAs, including their esterification and oxidation.

Long-chain fatty acid transport protein 1 (FATP1) is a protein that in humans is encoded by the SLC27A1 gene. [5][6] The SLC27A1 gene is located on the 19th chromosome, with its specific location being 19p13.11. The gene contains 15 exons. [6] .

Mar 20, 2016 · We hypothesized that specific lipid trafficking proteins, e.g. fatty acid transport protein 1 (FATP1), would direct MF fatty acid transport and metabolism to limit inflammation and contribute to the maintenance of adipose tissue homeostasis.

FATP1 and protein fragments have revealed that FATP1 forms homo-dimeric, and possibly higher-order, com-plexes, most likely through interactions in the cytoplas-mic loop between amino acids 191 and 475 [30] (Fig. 3A). It will be of great interest to determine whether other FATP family members also form homo-, and possibly, hetero-dimers.

Fatty acid transport protein 1 (FATP1), a member of the FATP/Slc27 protein family, enhances the cellular uptake of long-chain fatty acids (LCFAs) and is expressed in several insulin-sensitive tissues. In adipocytes and skeletal muscle, FATP1 translocates from an intracellular compartment to the plasma membrane in response to insulin.

Fatty acid transport proteins (FATPs, SLC27, SLC27A) are a family of trans-membrane transport proteins, which allow and enhance the uptake of long chain fatty acids into cells. [1] . This subfamily is part of the solute carrier protein family.

May 23, 2014 · FATP1 mediates skeletal muscle cell fatty acid import, yet its intracellular localization and metabolic control role are not completely defined. Here, we examine FATP1 localization and metabolic effects of its overexpression in mouse skeletal muscle.

Jul 11, 2003 · In humans FATPs comprise a family of six highly homologous proteins, hsFATP1–6, which are found in all fatty acid-utilizing tissues of the body. This review will focus on a brief discussion of FATP expression patterns, regulation, structure, and mechanism of transport.

Nov 20, 2023 · Fatty acid transport protein 1 (FATP1) is an integral transmembrane protein that is involved in facilitating the translocation of long-chain fatty acids (LCFA) across the plasma membrane, thereby orchestrating the importation of LCFA into the cell.

Biochemical, imaging, and functional analysis revealed that FATP1 and DGAT2 form a conserved protein complex at the ER–LD interface to promote LD expansion. Our results suggest one mechanism for triacylglycerol (TAG) synthesis and channeling that links ER and LD through a macromolecular complex.