Intra- and inter-molecular regulation by intrinsically-disordered ...
2023年11月13日 · Caenorhabditis elegans PUF protein fem-3 binding factor-2 (FBF-2) partners with intrinsically disordered Lateral Signaling Target-1 (LST-1) to regulate target mRNAs in …
The Puf RNA-binding proteins FBF-1 and FBF-2 inhibit the …
2010年6月1日 · FBF-1 and FBF-2 (collectively FBF) are two nearly identical Puf-domain RNA-binding proteins that regulate the switch from mitosis to meiosis in the C. elegans germline. In …
Diverse Roles of PUF Proteins in Germline Stem and Progenitor …
2020年2月6日 · This review summarizes the many roles of PUF-8, FBF-1, and FBF-2 in germline stem and progenitor cells (SPCs) and discusses the factors accounting for their distinct …
The PUF RNA-binding protein, FBF-2, maintains stem cells without ...
2024年10月25日 · Here we report that an FBF-2 mutant protein that cannot bind to RNA, is nonetheless biologically active and maintains stem cells. This unexpected result challenges …
RCSB PDB - 7S02: Crystal structure of FBF-2 in complex with LST-1 …
2021年8月28日 · Here we focus on understanding how the essential partner protein, LST-1, modulates mRNA regulation by the PUF protein, FBF-2. LST-1 contains two nonidentical sites …
Intra- and inter-molecular regulation by intrinsically-disordered ...
2023年11月13日 · Caenorhabditis elegans PUF protein fem-3 binding factor-2 (FBF-2) partners with intrinsically disordered Lateral Signaling Target-1 (LST-1) to regulate target mRNAs in …
Bipartite interaction sites differentially modulate RNA-binding ...
2022年1月11日 · Here we focus on understanding how the essential partner protein, LST-1, modulates mRNA regulation by the PUF protein, FBF-2. LST-1 contains two nonidentical sites …
The PUF RNA-binding protein, FBF-2, maintains stem cells
2024年10月25日 · Here we report that an FBF-2 mutant protein that cannot bind to RNA, is nonetheless biologically active and maintains stem cells. This unexpected result challenges …
PUF family proteins FBF-1 and FBF-2 regulate germline stem and ...
2019年10月31日 · Through investigating the regulation of germline stem cells by two PUF family RNA-binding proteins FBF-1 and FBF-2 in C. elegans, we find that FBF-1 restricts …
A conserved RNA-binding protein controls germline stem cells in
2002年5月22日 · Here we report that FBF also controls germline stem cells: in an fbf-1 fbf-2 double mutant, germline proliferation is initially normal, but stem cells are not maintained. We …