FBXL3 is a gene in humans and mice that encodes the F-box/LRR-repeat protein 3 (FBXL3). [5] [6] FBXL3 is a member of the F-box protein family, which constitutes one of the four subunits in the SCF ubiquitin ligase complex. [7]

2024年12月25日 · FBXL3 (F-Box And Leucine Rich Repeat Protein 3) is a Protein Coding gene. Diseases associated with FBXL3 include Intellectual Developmental Disorder With Short Stature, Facial Anomalies, And Speech Defects and Epilepsy. Among its related pathways are Class I MHC mediated antigen processing and presentation and Chaperonin-mediated protein folding.

fbxl3基因能够通过形成scf复合物行使e3泛素连接酶功能参与生物钟调控，并且fbxl3蛋白参与负反馈环，通过促进cry1和cry2蛋白降解过程，进而影响哺乳动物的昼夜节律 。

2013年3月17日 · The SCF FBXL3 ubiquitin ligase complex (SKP1–CUL1–F-box protein complex containing the F-box protein FBXL3) has been identified to regulate the clock by promoting the degradation of CRYs.

2025年2月9日 · FBXL3 was regulated by miR-4735-3p and suppressed cell proliferation and invasion in non-small cell lung cancer. data indicate an oncogenic role of miR-181d in CRC by promoting glycolysis, and miR-181d/CRY2/FBXL3/c-myc feedback loop might be a therapeutic target for patients with CRC.

FBXL3 mediated degradation of CRY1 and CRY2 can re-activate the CLOCK-BMAL1 complex and increase the protein levels of period circadian protein homolog 1 (PER1) and 2 (PER2), two circadian clock regulators with tumor suppressor activity 49.

F-box 蛋白构成称为 SCF (SKP1-cullin-F-box) 的泛素蛋白连接酶复合物的四个亚基之一，其在磷酸化依赖性泛素化中发挥作用。 F-box 蛋白分为 3 类：包含 WD-40 结构域的 Fbws、包含富含亮氨酸重复序列的 Fbls 和包含不同蛋白质-蛋白质相互作用模块或无可识别基序的 Fbxs。 该基因编码的蛋白质属于 Fbls 类，除了 F-box 外，还包含几个串联的富含亮氨酸的重复序列，位于细胞核中。 [RefSeq 提供，2008 年 7 月]

2020年11月25日 · F-box proteins (FBPs) are substrate-recruiting subunits of Skp1-cullin1-FBP (SCF)-type E3 ubiquitin ligases that determine which proteins are ubiquitinated. To date, around 70 FBPs have been identified in humans and can be subdivided into distinct families, based on the protein-recruiting domains they possess.

2025年1月5日 · 本文将详细介绍fbxl3基因的遗传变异及其生物学意义，包括该基因的多态性、单核苷酸多态性（snp）以及遗传变异与表型的关系。 什么是FBXL3基因？ FBXL3基因，全称为F-box and leucine rich repeat protein 3，位于染色体13q22.3上。

FBXL3的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为该基因编码在F-box蛋白家族，其特征是一个约40个氨基酸基序，在F-盒的成员。