F-box only protein 7 is a protein that in humans is encoded by the FBXO7 gene. [5][6][7][8] Mutations in FBXO7 have been associated with Parkinson's disease. [9][10] This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box.

2024年12月25日 · FBXO7 (F-Box Protein 7) is a Protein Coding gene. Diseases associated with FBXO7 include Parkinson Disease 15, Autosomal Recessive Early-Onset and Parkinson Disease 2, Autosomal Recessive Juvenile. Among its related pathways are Class I MHC mediated antigen processing and presentation and Metabolism of proteins.

2023年1月30日 · F-box protein 7 (FBXO7) is a unit in the SKP1-Cullin1-F-box (SCF) SCF FBXO7 E3 ligase composite, playing the role of recognizing some substrates. Additionally, FBXO7 is involved in the regulation of the proteasome complex, mitophagy, the cell cycle, cell proliferation, and germ cell differentiation.

2024年6月5日 · Here, we show the E3 ubiquitin ligase F-box-only protein 7 (FBXO7) inhibits serine synthesis in HCC by binding PRMT1, inducing lysine 37 ubiquitination, and promoting proteosomal degradation of...

2025年2月9日 · FBXO7, a tumor suppressor in endometrial carcinoma, suppresses INF2-associated mitochondrial division. The characteristics of FBXO7 and its role in human diseases. Novel bi-allelic FBXO7 variants in a family with early-onset typical Parkinson's disease. Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells.

2024年6月11日 · 进一步研究发现，FBXO7可介导PRMT1第37位赖氨酸泛素化修饰和蛋白酶体降解，从而降低PHGDH的精氨酸甲基化水平，抑制丝氨酸合成，诱导氧化应激，在体内外抑制肝癌细胞生长。

2023年10月30日 · 该研究确定FBXO7是GBM肿瘤发生、MES转化和耐药的关键调节因子，发现FBXO7通过K63连接的泛素化稳定Rbfox2，并控制Rbfox2介导的间充质基因的选择性剪接，从而促进GBM MES转化和化疗耐药。

Ubiquitous expression in bone marrow (RPKM 94.0), thyroid (RPKM 68.7) and 25 other tissues. 该基因编码 F-box 蛋白家族的一个成员，其特征在于大约 40 个氨基酸基序，即 F-box。 F-box 蛋白构成称为 SCF (SKP1-cullin-F-box) 的泛素蛋白连接酶复合物的四个亚基之一，其在磷酸化依赖性泛素化中发挥作用。 F-box 蛋白分为 3 类：包含 WD-40 结构域的 Fbws、包含富含亮氨酸重复序列的 Fbls 和包含不同蛋白质-蛋白质相互作用模块或无可识别基序的 Fbxs。 该基因编码的 …

Title: The F-box protein, FBXO7, is required to maintain chromosome stability in humans. FBXO7 triggers caspase 8-mediated proteolysis of the transcription factor FOXO4 and exacerbates neuronal cytotoxicity.

FBXO7 controls Rbfox2-mediated splicing of mesenchymal genes, including FoxM1, Mta1, and Postn. FBXO7-induced exon Va inclusion of FoxM1 promotes FoxM1 phosphorylation by MEK1 and nuclear translocation, thereby upregulates CD44, CD9, and ID1 levels, resulting in GBM stem cell self-renewal and mesenchymal transformation.