The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high- affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotype involved in allergy disorders and parasite immunity. FcεRI is a tetrameric receptor complex that binds Fc portion of the ε heavy chain of IgE. [1] .

2022年2月11日 · FcεRI, a high-affinity IgE receptor, deciphers the Ag-IgE interaction and drives allergic responses. FcεRI clustering is essential for signal transduction and, therefore, determines the quality of MC responses.

FcεRI, a high-affinity IgE receptor, deciphers the Ag–IgE interaction and drives allergic responses. FcεRI clustering is essential for signal transduction and, therefore, determines the quality of MC responses.

2024年8月21日 · FcεRI is a tetrameric complex, comprising FcεRIα, FcεRIβ and a homodimer of FcRγ (originally known as FcεRIγ), with FcεRIα recognizing the Fc region of IgE (Fcε) and FcεRIβ–FcRγ facilitating signal...

2024年10月25日 · IgE的高亲和Fc受体（FcεRI）主要存在于肥大细胞和嗜碱性细胞中，在过敏性疾病中起重要作用。 单体IgE结合FcεRI调控肥大细胞的存活、分化和成熟。 然而，潜在的分子机制仍不清楚。 2024年10月23日，西湖大学施一公及宿强共同通讯在Nature在线发表题为“Molecular mechanism of IgE-mediated FcεRI activation”的研究论文，该研究首次揭示了IgE介导的FcεRI激活的分子机制。 该研究表明，在IgE结合之前，FcεRI主要以-二聚体形式存在于人肥大细胞膜上 …

FcεRI is a multimeric immune Fc receptor that binds IgE with high affinity. It has a tetrameric structure on the surface of mast cells and basophils, consisting of one IgE-binding α-chain, one...

2024年10月23日 · In this study, we report the full-length FcεRI structure at 3.8 Å resolution using cryo-electron microscopy (cryo-EM). Through experimental analyses, we identified a functionally important FcεRI...

2019年1月17日 · FCERI signaling in mast cells includes a network of signaling molecules and adaptor proteins. These molecules coordinate ultimately leading to effects on degranulation, eicosanoid production, and cytokine and chemokine production and cell migration and adhesion, growth and survival.

Type I allergic reactions, such as allergic rhinoconjunctivitis, allergic asthma and anaphylactic urticaria, are characterized by elevated levels of serum IgE including allergen-specific IgE. In their monomeric form, these IgE molecules are capable of binding to the high affinity receptor for IgE (FcεRI) on mast cells and basophils.

2005年1月1日 · 摘要 通过高亲和力 IgE 受体 (FceRI) 预防效应细胞活化被认为是抑制过敏反应的直接策略。 在众多防止通过 FceRI 激活的方法中，本文介绍了三个版本。 第一个和第二个想法分别涉及抑制 FceRI 和 IgE 与可溶形式的 FceRI α 链和针对α链的人源化抗体之间的结合。

Fc epsilon 受体 (FcεR) 是结合免疫球蛋白 E (IgE) 的 Fc 受体。 FcεR 有两种类型，称为 FcεRI （即高亲和力 Fc epsilon R，Kd ~1nm） 和 FcεRII/CD23（即低亲和力 Fc epsilon R，Kd 0.1-1μm）。 FceRI 和 FcεRII/CD23 的分子结构差异很大。 FceRI 属于免疫球蛋白超家族，在序列和结构上与 IgG Fc 受体高度同源，而 CD23 是 C 型凝集素超家族的成员。 CD23 在 B 细胞、多种先天细胞类型和上皮细胞上表达。 除了肥大细胞和嗜碱性粒细胞外，FcεRI 也在多种细胞上表达 …

IgE antibodies bind to the high-affinity IgE receptor, FcεRI, expressed on the surface of mast cells; antigen-induced cross-linking of FcεRI-bound IgE molecules activates the mast cell to release an array of proinflammatory and immunomodulatory mediators.

2005年1月1日 · Prevention of the effector cell activation via high affinity IgE receptor (FcεRI) is thought to be a straightforward strategy for suppressing the allergic reaction. Among the numerous methods to prevent the activation through FcεRI, three versions are …

The high affinity IgE receptor (FceRI) plays a central role in allergic diseases including asthma, allergic rhinitis, atopic dermatitis, food and drug allergy. Manipulating the function of this receptor is important for controlling the onset of allergic diseases.

2022年2月11日 · FcεRI, a high-affinity IgE receptor, deciphers the Ag–IgE interaction and drives allergic responses. FcεRI clustering is essential for signal transduction and, therefore, determines the quality...

IgE antibodies play a paramount role in the pathogenesis of various intestinal disorders. To gain insights in IgE-mediated pathophysiology of the gut, we investigated the expression of the high affinity IgE receptor FcεRI in human intestinal epithelium.

As with IgE itself, immediate hypersensitivity is defined by the presence of the high-affinity IgE receptor, FcεRI, because only by binding to this receptor on the plasma membrane of cells is the antigen specificity of IgE conferred to the cellular reac-tion.

Fc epsilon receptor (FCERI) signaling Mast cells (MC) are distributed in tissues throughout the human body and have long been recognized as key cells of type I hypersensitivity reactions. They also play important roles in inflammatory and immediate allergic reactions.

1999年11月25日 · In humans, FcεRI controls the activation of mast cells and basophils, and participates in IgE-mediated antigen presentation. Multivalent antigens bind and crosslink IgE molecules held at the cell...

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