The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high- affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotype involved in allergy disorders and parasite immunity. FcεRI is a tetrameric receptor complex that binds Fc portion of the ε heavy chain of IgE. [1] .

2024年12月25日 · High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation.

1999年11月25日 · In humans, FcεRI controls the activation of mast cells and basophils, and participates in IgE-mediated antigen presentation. Multivalent antigens bind and crosslink IgE molecules held at the cell...

The analysis demonstrates the higher expression of FcER1 in more advanced stages of diabetes. The toll-like receptor signaling pathway is the topmost enriched pathway with all the upregulated genes. FcER1, ITGAX, SLC12A7 are a few of the top 30 significant genes, whose expression increased with the severity of diabetes (Supplementary Table 1).

2021年12月1日 · In conclusion, we demonstrate how leveraging public and private human transcriptional datasets can discover and validate innate immunity and inflammation as key mechanistic pathways in DKD progression, and uncover FcER1 as a putative new DKD target for rational drug design.

2024年12月25日 · FCER1G (Fc Epsilon Receptor Ig) is a Protein Coding gene. Diseases associated with FCER1G include Bleeding Disorder, Platelet-Type, 11 and Cd3zeta Deficiency. Among its related pathways are Innate Immune System and CLEC7A (Dectin-1) signaling.

在 dkd 肾小球中 325 个显着上调的基因中（p < 0.05），28 个在 pbmc 和糖尿病肾中重叠，受干扰的 fcer1 信号传导是显着丰富的典型途径。 FcER1 被证实在晚期 DKD 中显着增加，其中还发现它在肾活检中与组织肥大细胞特异性共表达。

FcER1: A Novel Molecule Implicated in the Progression of Human Diabetic Kidney Disease. Genetic association study of CTLA4 and FCepsilonRIalpha polymorphisms in asthmatic patients in the southwestern region of Iran. Inverse association of FCER1A allergy variant in monocytes and plasmacytoid dendritic cells.

免疫球蛋白ε受体 (IgE 受体) 是过敏反应的引发剂。 当两个或多个高亲和力 IgE 受体被过敏原结合的 IgE 分子聚集在一起时，会释放引起过敏症状的介质，例如组胺。 该受体由一个α亚基、一个β亚基和两个γ亚基组成。 该基因编码的蛋白质代表α亚基。 [RefSeq 提供，2011 年 8 月] The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response.

The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high- affinity receptor for the Fc region of immunoglobulin E (IgE), an antibody isotype involved in the allergy disorder and parasites immunity. FcεRI is a tetrameric receptor complex that binds Fc portion of the ε heavy chain of IgE. [ 1 ] .

2025年1月4日 · Title: FcER1: A Novel Molecule Implicated in the Progression of Human Diabetic Kidney Disease. Genetic association study of CTLA4 and FCepsilonRIalpha polymorphisms in asthmatic patients in the southwestern region of Iran.

2024年7月16日 · FcεR1γ expression in ILC3s is essential for effective protective immunity against bacterial and fungal infections. Mechanistically, FcεR1γ influences the transcriptional state and...

IgE antibodies bind to the high-affinity IgE receptor, FcεRI, expressed on the surface of mast cells; antigen-induced cross-linking of FcεRI-bound IgE molecules activates the mast cell to release an array of proinflammatory and immunomodulatory mediators.

Allergen sensitization triggers a feedforward inflammatory loop between IgE-producing plasma cells, FcεR1-expressing vagal sensory neurons, and T_H2 cells, which helps to both initiate and amplify allergic airway inflammation. These data highlight a novel target for reducing allergy, namel …

2022年6月29日 · FCER1G-expressing αβ TCR lineage innate-like T cells with high cytotoxic potential (αβILTCKs) are an evolutionarily conserved innate-type T cell that develops from a …

2021年12月1日 · In conclusion, we demonstrate how leveraging public and private human transcriptional datasets can discover and validate innate immunity and inflammation as key mechanistic pathways in DKD...

具有IgE结合活性和IgE受体活性。 在几个过程的上游或内部发挥作用，包括白细胞三烯生物合成过程；免疫应答的正调控；和大分子代谢过程的正调控。 位于质膜的外侧。 是质膜的整合成分。 与人类的FCER1A（IgE受体Ia的Fc片段）正同源。 [由基因组资源联盟，2022年4月提供] Dir./Indir. Functional annotation of a full-length mouse cDNA collection. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

高亲和力 IgE 受体是参与过敏反应的关键分子。 它是由 1 条 α、1 条 β 和 2 条 γ 链组成的四聚体。 γ 链也是其他 Fc 受体的亚基。 [RefSeq 提供，2008 年 7 月] The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other …

FCER1A是高亲和力IgE受体的α亚基，与IgE分子的Fc区域结合，是一种高亲和力受体。 FCER1A的作用机制涉及与过敏原结合的IgE分子聚集，导致细胞激活和释放如组胺等介质，引发过敏反应。 FCER1A在过敏反应中发挥关键作用，其激活导致炎症和即时超敏反应，这些反应是如花粉热和哮喘等过敏性疾病的特征。 (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

By suppressing the expression of FCER1 and HRH4 genes, probiotic lactobacilli could attenuate mast-cell activation and release of allergy-related mediators. To obtain more evidence of the possible ability of probiotics to suppress mast-cell activation, the array gene set was manually screened for other genes involved in IgE receptor signaling.