2020年6月4日 · Ferredoxin reductase (FDXR) is a mitochondrial membrane-associated flavoprotein. One of its functions is to transfer electrons from NADPH to the two human ferredoxin proteins,...

2022年10月24日 · Human mitochondria contain two isoforms of [2Fe-2S] ferredoxins, FDX1 (aka adrenodoxin) and FDX2, with known functions in cytochrome P450-dependent steroid transformations and Fe–S protein...

Human mitochondria contain two isoforms of [2Fe-2S] ferredoxins, FDX1 (aka adrenodoxin) and FDX2, with known functions in cytochrome P450-dependent steroid transformations and Fe–S protein biogenesis. Here, we show that only FDX2, but …

Here, we show that FDXR plays a role in tumorigenesis by modulating expression of the tumor suppressor p73. By using genetically modified mouse models, we recently showed that mice deficient in either Fdxr or Trp73 had a shorter lifespan and were prone to spontaneous tumors as compared with wild-type (WT) mice.

2024年1月22日 · The iron-sulfur cluster containing Ferredoxin 1 (FDX1), critical in steroidogenesis and TCA cycle, is required for mammalian embryonic development and maintenance of lipid homeostasis at cellular and organismal levels.

2024年1月22日 · Mammalian ferredoxin 1 and 2 (FDX1/2) belong to an evolutionary conserved family of iron-sulfur cluster containing proteins and act as electron shutters between ferredoxin reductase (FDXR) and numerous proteins involved in critical biological pathways. FDX1 is involved in biogenesis of steroids and …

2021年8月15日 · Insulin-like growth factor-1 (IGF-1)-induced FDXR and PPARγ expression and lipogenesis were abolished by pretreatment with PI3K inhibitor LY294002. These results suggest that FDXR overexpression might promote differentiation and lipogenesis via ROS production and suppress proliferation via G2/S blockade in SZ95 sebocytes.

该基因编码一种线粒体黄素蛋白，它启动细胞色素 P450 的电子传输，从 NADPH 接收电子。 已发现该基因的多个选择性剪接转录物变体。 [RefSeq 提供，2012 年 4 月] This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

2018年9月25日 · Recently, we have identified biallelic mutations in the mitochondrial flavoprotein “ferredoxin reductase” (FDXR) gene as a novel cause of mitochondriopathy, peripheral neuropathy, and optic ...

哺乳动物肾上腺素氧还蛋白（铁氧还蛋白 1；Fdx1）对于肾上腺中各种类固醇激素的合成至关重要。 作为含 [2Fe-2S] 簇的铁氧还蛋白家族的成员，Fdx1 减少线粒体细胞色素 P450 酶，然后催化；例如，胆固醇转化为孕烯醇酮、醛固酮和皮质醇。