The "Acid Box" The FGF receptors typically contain three Ig-like binding domains (with domains D2 and D3 being most involved in FGF-FGF receptor binding interactions), a short transmembrane spanning domain and a cytoplasmic component that …

1974年，英国科学家Gospodarowicz从牛的脑垂体中首次分离出能促进成纤维细胞生长的物质，将其命名为 成纤维细胞生长因子 （Fibroblast Growth Factor, FGF）。 FGFs在细胞增殖、组织修复和再生、血管生成中扮演着重要作用。

fgf与fgfr结合，调控下游信号通路，在促分裂（胚胎发生、生长发育等）和非促分裂（神经调节、代谢调节等）均其中重要的作用。 FGFR的高表达、突变等会导致信号通路的异常激活，FGFR通路促分裂作用不受控制，导致肿瘤的发生。

Box 1. Fibroblast homologous factors. Although fibroblast homologous factors (FHFs) have high sequence and structural homology with fibroblast growth factors (FGFs) and bind heparin with high affinity, they do not activate FGF receptors (FGFRs).

The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of proteins. Some of these receptors are involved in pathological conditions. For example, a point …

fgf通过与 成纤维细胞生长因子受体 （fgfr）介导的信号轴刺激或维持代谢、组织稳态和发育所需的特定细胞功能，主要调节细胞增殖，分化，存活，迁移和代谢。

2006年11月17日 · Identification of the FGFR Acid Box as a Motif Required for NCAM Interactions—We next co-transfected L6 cells with the 125-kDa GPI-anchored NCAM and the various FGFR1 deletion

fgf与fgfr结合，调控下游信号通路，在促分裂（胚胎发生、生长发育等）和非促分裂（神经调节、代谢调节等）均其中重要的作用。 FGFR的高表达、突变等会导致信号通路的异常激活，FGFR通路促分裂作用不受控制，导致肿瘤的发生。

2019年4月21日 · The FGF signalling pathway comprises 4 highly conserved transmembrane receptors and 18 FGF ligands (Box 1). FGFs bind with low affinity to cell surface HSPGs (purple) and with high affinity to specific FGFRs.

2012年1月1日 · Fibroblast growth factor receptor (FGFR) autoinhibition mediated by the alternatively spliced immunoglobulin (Ig) domain 1 (D1) and the acid box (AB)-containing linker between D1 and Ig domain 2 (D2) serves as the first line …