FGF-8 is expressed in the region where Otx2 and Gbx2 cross inhibit each other and is maintained expression by this interaction. Once expressed, the Fgf8 induces other transcription factors to form cross-regulatory loops between cells, thus the border is established.

2025年1月10日 · This comprehensive review explores the FGF8 expression in humans and mice, summarizes the involvement of FGF8 in various tissues including craniofacial, limbs, cardiovascular and urogenital system, nephrogenesis, lung, and brain development as well as developmental abnormalities resulting from the aberrant regulations of FGF8 such as skeletal ...

2024年12月25日 · FGF8 (Fibroblast Growth Factor 8) is a Protein Coding gene. Diseases associated with FGF8 include Hypogonadotropic Hypogonadism 6 With Or Without Anosmia and Holoprosencephaly 1. Among its related pathways are Downstream signaling of activated FGFR2 and Apoptotic Pathways in Synovial Fibroblasts.

fgf8亚科：该fgf8亚科由fgf8，17，18组成。这个亚科的成员含有1个n端裂解信号肽。这些fgf激活fgf受体1-3和fgf受体4的c部剪接变异体。 fgf9亚科：该fgf9亚家族包括fgf9，16，20。这亚科没有典型的n端信号肽，但含内部疏水序列，内部疏水序列的功能是作为一个非切割的 ...

FGF8, FGF17, and FGF18 are involved in autocrine and paracrine signaling in HCC and enhance the survival of tumor cells under stress conditions, malignant behavior, and neoangiogenesis. FGF8b is able to induce fast growth in strongly hypoxic tumour microenvironment whereas VEGF-stimulated growth advantage is associated with improved perfusion ...

Fibroblast growth factor (FGF) 8 (FGF8) signaling regulates neuroendocrine progenitor cell proliferation, fate specification, and cell survival and has therefore been hypothesized to be critical for the development and maintenance of homeostatic systems in the body such as the hypothalamus–pituitary–axis (HPG) (1 – 5).

成纤维细胞生长因子8（fibroblast growth factor 8, FGF8）在生物体整个生命历程中发挥着许多功能。 FGF8的表达异常可能会导致骨骼稳态紊乱和发育畸形。 研究表明FGF8在骨骼发育中发挥重要作用，并有可能作为靶标发挥治疗功能。 本综述针对FGF8在多种骨骼异常疾病中的作用进行总结，以期为今后相关疾病的防治开拓新的视野。 The proper development and the homeostasis maintenance of bones are important prerequisites for the normal functioning of the human body.

2024年12月10日 · Title: Mutations in fibroblast growth factor (FGF8) and FGF10 identified in patients with conotruncal defects. FGF8 induces epithelial-mesenchymal transition and promotes metastasis in oral squamous cell carcinoma.

2024年11月1日 · The morphogen FGF8 establishes graded positional cues imparting regional cellular responses via modulation of early target genes. The roles of FGF signaling and its effector genes remain poorly characterized in human experimental models mimicking early fetal telencephalic development.

该基因编码的蛋白质是成纤维细胞生长因子 (FGF) 家族的成员。 FGF 家族成员具有广泛的促有丝分裂和细胞存活活性，并参与多种生物过程，包括胚胎发育、细胞生长、形态发生、组织修复、肿瘤生长和侵袭。 已知该蛋白质是支持雄激素和不依赖锚定的乳腺肿瘤细胞生长的因子。 该基因的过度表达已被证明会增加肿瘤生长和血管生成。 该基因的成人表达仅限于睾丸和卵巢。 该基因表达的时间和空间模式表明其作为胚胎上皮因子的功能。 对小鼠和小鸡同系物的研究揭示了在 …