Hosted dimerization: Proteins such as yellow fluorescent protein (YFP) with an N-terminal FGG peptide motif form dimers mediated by supramolecular interactions with cucurbit[8]uril (see scheme). The protein dimerization, which is observed by FRET and size-exclusion chromatography, can be reversed with methyl viologen as a bioorthogonal ligand ...

2019年3月20日 · Here, we show that the blood protein fibrinogen induces spine elimination and promotes cognitive deficits mediated by CD11b-CD18 microglia activation. 3D molecular labeling in cleared mouse and human AD brains combined with repetitive in vivo two-photon imaging showed focal fibrinogen deposits associated with loss of dendritic spines independent...

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Hosted dimerization: Proteins such as yellow fluorescent protein (YFP) with an N‐terminal FGG peptide motif form dimers mediated by supramolecular interactions with cucurbit[8]uril (see scheme). The protein dimerization, which is observed by FRET and size‐exclusion chromatography, can be reversed with methyl viologen as a bioorthogonal ...

2022年2月7日 · The incorporation of a dimerizing interface at the fluorescent protein surface (dYFP, dCFP) combined with an encoded N-terminal phenylalanine-glycine-glycine (FGG) peptide motif allowed cucurbit[8]uril to selectively recognize and induce FGG-dYFP or FGG-dCFP homotetramerization.

2015年1月13日 · The interplay of Phe-Gly-Gly (FGG)-tagged proteins and bivalent FGG-tagged penta(ethylene glycol) as guest molecules with cucurbit[8]uril (Q8) hosts is studied to modulate the supramolecular ...

黄色荧光蛋白（英語： Yellow Fluorescent Protein ，缩写YFP）是一种绿色荧光蛋白（GFP）的变体 [1] ，能发出黄色 荧光（激发峰517nm，发射峰527nm） [2] ，从GFP变为YFP至少需要蛋白质序列上四个氨基酸残基（aa）发生改变，其中最重要的是203号位的苏氨酸变为酪氨酸 ...

遗传性纤维蛋白原异常 (inherited abnormalities of fibrinogen)是由于纤维蛋白原 (fibrinogen，Fib)的基因突变，导致合成的Fib数量和（或）功能异常，Fib数量上的减少，称为异常纤维蛋白原血症I型 (type ldefiaency)、无纤维蛋白原血症 (afibrinogenemia)或纤维蛋白原缺乏症 (hypofibrinogenemia)；功能上的异常称为异常纤维蛋白原血症Ⅱ型 (typeⅡdeficiencies)、异常纤维蛋白原血症 (dysfibrinogenemia或hypodysfibrinogenemia)。 Fib的3条肽链分别由簇集于4号染 …

The fibrinogen genes (FGB-FGA-FGG) are expressed almost exclusively in hepatocytes where their output is coordinated to ensure a sufficient mRNA pool for each chain and maintain an abundant plasma fibrinogen protein level.

2024年5月7日 · 由4号染色体长臂上编码纤维蛋白原三个多肽链的基因（FGA、FGB和FGG）突变导致。 患者男，69岁。 主因间断无痛血尿、尿频、尿急3月于2023年11月22于我院综合急诊外科门诊就诊。 门诊辅助检查：超声检查膀胱、前列腺、测残余尿示：膀胱实性占位前列腺增大伴钙化斑形成；腹部CT平扫：1、膀胱壁增厚，考虑膀胱占位？ 建议强化；2、前列腺肥大伴钙化。 请结合临床进一步诊断和鉴别诊断。 实验室检查：尿干化学+尿沉渣分析:红细胞1784.9p/ul,白细 …