2024年12月25日 · FLNA (Filamin A) is a Protein Coding gene. Diseases associated with FLNA include Melnick-Needles Syndrome and Otopalatodigital Syndrome, Type Ii. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Signaling by Rho GTPases.

Thirty-five years of FLNa research has revealed its structure in great detail, discovered its isoforms (FLNb and c), and identified over 90 binding partners including channels, receptors, intracellular signaling molecules, and even transcription factors.

2021年6月5日 · Filamin A (FLNa) is an actin-binding protein, which participates in the formation of the cytoskeleton, anchors a variety of proteins in the cytoskeleton and regulates cell adhesion and migration.

2004年11月1日 · Filamin was discovered as the first non-muscle actin binding protein almost 30 years ago. The three filamin isoforms in mammals (FLNA, B and C) are large cytoplasmic proteins that play important...

The FLNA gene provides instructions for producing the protein filamin A, which helps build cells' extensive internal network of protein filaments called the cytoskeleton. Learn about this gene and related health conditions.

The filamins (FLN) are a family of actin binding proteins that can convert, via non-covalent cross-linking, a solution of semi-flexible F-actin filaments into a gel of increased elastic stiffness at a critical concentration of FLN (Wang and Singer 1977).

Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes. They integrate cellular architectural and signalling functions...

Filamins are essential, evolutionary conserved, modular, multi-domain, actin-binding proteins that organize the actin cytoskeleton and maintain extracellular matrix connections by anchoring actin filaments to transmembrane receptors.

Thirty five years of FLNa research has revealed its structure in great detail, discovered its isoforms (FLNb and c), and identified over 90 binding partners including channels, receptors, intracellular signaling molecules, and even transcription factors.

Filamin A is an actin binding protein produced by the FLNA gene, which is expressed by migrating neurons in the prenatal neocortex (Fox et al., 1998).