Filamins are a class of proteins that hold two actin filaments at large angles. [1] . Filamin protein in mammals is made up of an actin-binding domain at its N-terminus that is followed by 24 …

2021年6月5日 · Filamin A (FLNa) is an actin-binding protein, which participates in the formation of the cytoskeleton, anchors a variety of proteins in the cytoskeleton and regulates cell adhesion …

Filamin A (FLNa) is the first actin filament cross-linking protein or gelation factor identified in non-muscle cells, 1 and we now understand its structure in great detail.

2004年11月1日 · Filamin was discovered as the first non-muscle actin binding protein almost 30 years ago. The three filamin isoforms in mammals (FLNA, B and C) are large cytoplasmic …

Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes. They integrate cellular architectural and signalling functions...

2021年6月5日 · Filamin A (FLNa) is an actin-binding protein, which participates in the formation of the cytoskeleton, anchors a variety of proteins in the cytoskeleton and regulates cell adhesion …

Thirty five years of FLNa research has revealed its structure in great detail, discovered its isoforms (FLNb and c), and identified over 90 binding partners including channels, receptors, …

2024年12月25日 · FLNA (Filamin A) is a Protein Coding gene. Diseases associated with FLNA include Melnick-Needles Syndrome and Otopalatodigital Syndrome, Type Ii. Among its related …

Filamins are essential, evolutionary conserved, modular, multi-domain, actin-binding proteins that organize the actin cytoskeleton and maintain extracellular matrix connections by anchoring …

The filamins are a group of homologous proteins defined by their high native molecular weight (500,000), their amino acid compositions, their cross-reactivity to antibodies to heterologous …