Bacterial Lectin FimH and Its Aggregation Hot-Spots: An …
Type I fimbriae are the main adhesive organelles of uropathogenic Escherichia coli (UPEC), consisting of four different subunits. Their component with the most important role in …
Catch-bond mechanism of the bacterial adhesin FimH - Nature
2016年3月7日 · We reveal a three-state mechanism of FimH catch-bond formation based on crystal structures of all states, kinetic analysis of ligand interaction and molecular dynamics …
Type 1 Fimbrial Adhesin FimH Elicits an Immune Response That …
The fimbrial tip-positioned adhesive protein FimH utilizes a shear force-enhanced, so-called catch-bond mechanism of interaction with its receptor, mannose, where the lectin domain of …
Use of fimH Single-Nucleotide Polymorphisms for Strain Typing of ...
In the present study, the usefulness of fimH single-nucleotide polymorphisms (SNPs) for Escherichia coli typing was explored. fimH SNPs were determined for 345 E. coli clinical …
FimH and Anti-Adhesive Therapeutics: A Disarming Strategy Against ...
2020年7月10日 · The best-characterized bacterial adhesin is FimH, produced by uropathogenic Escherichia coli (UPEC). Hence, a number of high-affinity mono- and polyvalent mannose …
Structure-based design of an immunogenic, conformationally …
2025年2月19日 · FimH is an adhesin positioned on the fimbrial tip which binds to mannosylated proteins on the urinary tract epithelium via its lectin domain (FimH LD). FimH is of interest as a …
Bacterial Lectin FimH and Its Aggregation Hot-Spots: An ... - MDPI
2023年3月22日 · Here, we propose that the amyloidogenic potential of FimH can be exploited for the development of therapeutic agents against Urinary Tract Infections (UTIs).
Escherichia coli adhesion portion FimH functions as an …
2020年3月4日 · In this study, we find that FimH, which is an Escherichia coli adhesion portion, induces toll-like receptor 4-dependent and myeloid differentiation protein 2-independent DC …
FimH confers mannose-targeting ability to Bacillus Calmette
rBCG-S.FimH is a novel BCG strain with significantly improved efficacy against bladder cancer. Since intravesical BCG immunotherapy is the first-line treatment for NMIBC, which accounts …
Blockage of bacterial FimH prevents mucosal inflammation …
2021年8月23日 · To assess the pathogenic role of FimH, we used human intestinal explants and tested a specific FimH blocker to prevent bacterial adhesion and associated inflammation. We …