2024年12月25日 · FKBP10 (FKBP Prolyl Isomerase 10) is a Protein Coding gene. Diseases associated with FKBP10 include Bruck Syndrome 1 and Osteogenesis Imperfecta, Type Xi. Among its related pathways is Type I collagen synthesis in …

FK506-binding protein 10 is a protein that in humans is encoded by the FKBP10 gene. [5] [6] [7] The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase family. It is located in endoplasmic reticulum and acts as molecular chaperones. Two alternatively spliced variants, which encode different isoform, are ...

2024年1月17日 · Through bioinformatic analysis, we found that FK506 binding protein 10 (FKBP10) may play an essential role in hypoxia and glycolysis pathways in ccRCC progression. Functionally, FKBP10 promotes...

2025年2月8日 · FKBP10 promotes proliferation of glioma cells via activating AKT-CREB-PCNA axis. FKBP10 functioned as a cancer-promoting factor mediates cell proliferation, invasion, and migration via regulating PI3K signaling pathway in stomach adenocarcinoma. New insights on the clinical variability of FKBP10 mutations.

2023年7月13日 · FKBP10, a member of the FK506-binding protein (FKBP) family, has been implicated in cancer development, although its prognostic function remains controversial. In this study, we analyzed the expression of FKBP10 in tumor tissues using online databases (TCGA) as well as our CRC cohort, and investigat …

2021年3月6日 · 而fkbp10 可以通过调控基因表达，使细胞凋亡，增殖，血管生成，应激反应，蛋白质运输等方式，影响基因及蛋白的正常表达，从而参与肿瘤性疾病的形成过程。迄今为止，fkbp10在肿瘤中的作用越来越受到关注。

Ubiquitous expression in placenta (RPKM 31.0), endometrium (RPKM 25.7) and 22 other tissues. 该基因编码的蛋白质属于 FKBP 型肽基-脯氨酰顺/反异构酶 (PPIase) 家族。 这种蛋白质定位于内质网并充当分子伴侣。 已经报道了编码不同亚型的选择性剪接变体，但它们的生物学有效性尚未确定。 [RefSeq 提供，2009 年 11 月] The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family.

FKBP脯氨酰异构酶10(FK506 binding protein 10,FKBP10)是编码FKBP65的基因,定位于17q21.1,属于FKBP型肽基脯氨酰顺反式异构酶家族,编码一组被称为免疫亲和素的蛋白质.它位于内质网中,起分子伴侣的作用.许多研究发现,FKBP10基因与多种疾病密切相关.本文就近年来FKBP10基因在疾病 ...

The FKBP10 gene provides instructions for making a protein that is found in a cell structure called the endoplasmic reticulum, which is involved in protein production, processing, and transport. The FKBP10 protein (formerly known as FKBP65) is important for the correct processing of complex molecules called collagen and elastin, which are part ...

fkbp是一个与免疫抑制剂fk506结合的蛋白家族，已有研究发现几种fkbps与癌细胞的生物学行为有关。fkbp10作为fkbp的家族成员之一，其位于第17号染色体(17q21.2)，因其编码的内质网伴侣蛋白分子量为65 kda, 故又称为fkbp65。fkbp10在发育过程中高度表达，成年后表达减弱。