2001年11月27日 · Flk-2 stimulated by the flt3 ligand has been implicated as both a survival and a proliferative signal of primitive hematopoietic progenitors, acting in synergy with the receptors for steel factor, IL-6, IL-11, granulocyte colony-stimulating factor, or thrombopoietin in enhancing the expansion of both murine (11, 13–16) and human (17–20 ...

Cluster of differentiation antigen 135 (CD135) also known as fms like tyrosine kinase 3 (FLT-3 with fms standing for "feline McDonough sarcoma"), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene.

2001年12月4日 · The loss of Thy-1.1 and gain of Flk-2 expression marks the loss of self-renewal in HSC maturation. The addition of Flk-2 antibody to the lineage mix allows direct isolation of LT-HSC from adult bone marrow as c-kit(+) lin(-) Sca-1(+) Flk-2(-) from many strains of mice.

6.1.5 cd135 (flk-2) cd135，又称flk-2、flt3和ly-72，是一种iii型酪氨酸激酶受体。cd135既表达在正常的cd34+造血干细胞中，也表达于恶性造血细胞，包括aml、all和cml bc。

1994年10月15日 · The flk-2/flt-3 receptor tyrosine kinase was cloned from a hematopoietic stem cell population and is considered to play a potential role in the developmental fate of the stem cell. Using antibodies derived against the extracellular domain of the receptor, we show that stem cells from both murine fetal liver and bone marrow can express flk-2/flt-3.

分析成年小鼠骨髓的KLS亚群的Flk-2和Thy-1.1表达。分离了三个表型和功能上不同的种群：Thy（lo）Flk-2（-）（LT-HSCs），Thy（lo）Flk-2（+）（ST-HSCs）和Thy（-）Flk-2（ +）多能祖细胞。Thy-1.1的丧失和Flk-2表达的增加标志着HSC成熟中自我更新的丧失。

We investigated the effect of Flk2 deficiency on myelopoiesis, focusing on specification of progenitors between HSC and mature cells. We provide evidence that Flk2 is critical for proliferative expansion of multipotent progenitors that are common precursors for all lymphoid and myeloid lineages, including megakaryocyte/erythroid (MegE) cells.

The novel hematopoietic growth factor FLT3 ligand (FL) is the cognate ligand for the FLT3, tyrosine kinase receptor (R), also referred to as FLK-2 and STK-1. The FLT3R belongs to a family of receptor tyrosine kinases involved in hematopoiesis that also includes KIT, the …

2007年11月16日 · FLT3/FLK2, a member of the receptor tyrosine kinase family, plays a critical role in maintenance of hematopoietic homeostasis, and the constitutively active form of the FLT3 mutation is one of the most common genetic abnormalities in acute myelogenous leukemia.

2006年2月1日 · In this study, Flk-2 is most frequently expressed in thyroid tumors, as compared with Flk-1 and c-Kit. The expression of Flk-2 was widely detected in both PTC and FTC, and to a lesser degree, in FA and NG samples (p = 0.005) (Table 1). These findings suggest that Flk-2 is involved in the pathogenic development of thyroid cancers.