Viral non-coding elements (NCEs) and NSPs play essential roles in FMDV-induced viral evasion. This review focus on the molecular biology of FMDV, along with the functional roles of FMDV NSPs and NCEs in viral replication and virulence, to elucidate how FMDV evades the host immune response and evolves into such an aggressive pathogen.

Foot and mouth disease (FMD) is a highly infectious viral disease caused by the FMDV belonging to the Picornaviridae family, a positive-sense, single-stranded RNA virus. FMDV primarily infects cloven-hoofed animals and is transmissible by aerosols and droplets, 2–4 and indirect (fomites) or direct contact. 5.

2025年1月17日 · Foot-and-mouth disease virus (FMDV) are small, icosahedral viruses that cause serious clinical symptoms in livestock. The FMDV VP1 protein is a key structural component, facilitating virus entry. Here, we find that the E3 ligase RNF5 interacts with VP1 and targets it for degradation through ubiquiti …

Foot-and-mouth disease virus (FMDV), the most acid-unstable virus among picornaviruses, tends to disassemble into pentamers at pH values slightly below neutrality. However, the structural integrity of intact virion is one of the most important factors that influence the induction of a protective antibody response.

2022年1月17日 · Using immunofluorescent confocal and electron microscopy, FMDV has been shown to dysregulate Golgi and ER-derived membranes in a similar way to PV 1, 5, 6, 32, 33, but distinct membrane-bound...

2021年2月18日 · FMDV enters host cells by integrin-mediated endocytosis, then disassociates into pentamers to release RNA in the acidic environment of the endocytic compartments. To investigate whether M8 or M170 interferes with the binding of FMDV to integrin, we performed competitive SPR-based binding assays.

FMDV has developed diverse strategies to escape the host interferon response. Here we demonstrate that FMDV infection interferes with the type II IFN signaling pathway and non-structural protein 3C inhibited IFN-'-stimulated inteferon-stimulated-genes (ISGs) mRNA synthesis and gamma-activated sequences (GAS) promoter activity.

Approach: Task 1. Expression and in vitro testing of Foot Mouth Disease Virus (FMDV) antigen proteins (capsids expressed in yeast or mammalian cells). Task 2. Examine viral proteins released from core-shell microneedles devise. Task 3. Testing and enhancing stabilized virus capsid proteins against temperature and pH in vitro. Task 4.

2016年6月22日 · Foot-and-mouth disease virus (FMDV) represses host translation machinery, blocks protein secretion, and cleaves cellular proteins associated with signal transduction and the...

2020年12月1日 · FMDV infection significantly increases the scale of miRNA-136 that inhibits the proliferation of FMDV in exosomes. Together, the current results indicated that 2C of FMDV degraded Rab27a via the autophagy-lysosome pathway to suppress exosome secretion.