IKK（inhibitor of kappa B kinase, kappa B 抑制因子激酶）参与胞内多种细胞信号转导途径，包括由细胞因子引起的细胞凋亡,其中最为人熟知的是可以通过磷酸化细胞质基质中与NF-κB【p65 …

This review highlights some of the major advances in the studies of the process of IKK activation and the biological roles of IKK family members, with a focus on NF-κB independent functions. …

2024年8月5日 · TANK-binding kinase 1 (TBK1) is a member of the IKK family and plays a crucial role in the activation of non-canonical NF-κB signaling and type I interferon responses. The …

This review highlights some of the major advances in the studies of the process of IKK activation and the biological roles of IKK family members, with a focus on NF-κB-independent functions. …

Gene-disruption studies provide evidence that IκB kinase (IKK) complex is essential to the activation of NF-κB signalling pathways. The two kinase subunits of the IKK complex, IKK-α …

As the primary, druggable mediator of canonical NF-κB signalling the IKKβ protein kinase has been the historical focus of drug development pipelines. Thousands of compounds with activity …

2013年4月1日 · In this review we will focus on p50/p65 NF-κB and IRF3, whose activation involves specific members of the inhibitor of κB (IκB) kinase (IKK) family. The canonical IKKs, …

2017年12月20日 · The IKK/NF-κB signaling system is a master regulator of inflammation, cell survival and differentiation, which also controls astrocyte functions, in particular their …

Inhibitory kappa B kinase beta (IKKβ), known as IKK2, is a key regulatory kinase responsible for the activation of NF-κB through its phosphorylation at Ser177 and Ser181 to promote the …

2021年3月1日 · IKK promotes cell survival during metabolic stress by phosphorylating substrates that favor energy conservation and recycling of metabolites. Cells sense energetic stress via …