Fodrin and its erythroid cell-specific isoform spectrin are actin-associated fibrous proteins that play crucial roles in the maintenance of structural integrity in mammalian cells, which is necessary for proper cell function. Normal cell morphology is altered in diseases such as various cancers and certain neuronal disorders.

Fodrin is a membrane-associated cytoskeletal protein important for maintaining normal membrane structure and supporting cell surface protein function. It forms a heterodimer with β-fodrin and is involved in exocytosis, secretion, and the apoptotic process. Its cleavage by caspases leads to membrane malfunction and cell shrinkage.

We have found that in the majority of cell types (lymphocytes, hepatocytes, neurons, fibroblasts) fodrin 235 K is present in the absence of the other two variant subunits, spectrin 220 K and TW260. Two cell types were found (skeletal muscle and …

2020年8月14日 · Fodrin和Spectrin是由旁系同源基因编码的双链（αβ）分子，具有许多特征，但也显示出一定的差异。 Fodrin（在人类中，通常是SPTAN1和SPTBN1基因产物的异二聚体）在几乎所有细胞类型中表达，并且在神经元组织中尤其丰富，而血影蛋白（在人类中，SPTA1和SPTB1基 …

In the present proteomic study, it was found that α-fodrin downregulation results in upregulation of RhoB and RhoC proteins. Fodrin is a large heterodimeric protein that houses two actin-binding calpain homology domains in its β-subunit. Fodrin’s association with actin is important for the integrity of the plasma membrane.

Fodrin is a major component of the cortical cytoskeleton of most eukaryotic cells, and it forms heterodimers aligned in a side-to-side manner composed of an α (240-kD) and a β (235-kD) subunit . α-Fodrin is an actin-binding protein that is found at the periphery of chromaffin cells and may be involved in secretion .

Fodrin (formerly designated 26 and 27) comprises two polypeptides (250,000 and 240,000 mol wt) that are axonally transported at a maximum time-averaged velocity of 40 mm/d--slower than the most rapidly moving axonally transported proteins, but faster than at …

2017年8月12日 · 细胞凋亡是机体清除衰老、畸变或恶化细胞的一种主动、程序化的生理过程，是多细胞生物维系其结构稳定和内环境功能平衡及生长发育必须的最基本的生物学过程 [2] 本文中就凋亡时细胞骨架蛋白的改变的研究进展作一综述。 1、细胞骨架的组成成分. 细胞骨架聚合物控制着真核细胞的形态和动力学特征，包括3种主要形式：肌动蛋白丝 (actinfilament，AF)、微管 (microtubule，MT)和中间丝 (intermediatefilament，IF)，三者被组装成网络结构来抵制细胞变 …

Alpha-Fodrin Antibody detects endogenous levels of full length alpha-fodrin (240 kDa) and its large fragment (150 kDa) resulting from cleavage at aspartic acid 1185.

Fodrin is an actin/calmodulin-binding protein with similarities to spectrin (erythrocytes) and TW 260/240 (brush border). It is concentrated beneath the plasma membranes of neurons and other cells. We have observed translocations of fodrin in both neurons and lymphocytes.