In chemistry, a foldamer is a discrete chain molecule (oligomer) that folds into a conformationally ordered state in solution. They are artificial molecules that mimic the ability of proteins, nucleic acids, and polysaccharides to fold into well-defined conformations, such as …

2007年4月16日 · Foldamers are sequence-specific oligomers akin to peptides, proteins and oligonucleotides that fold into well-defined three-dimensional structures. They offer the chemical...

Foldamers are artificial folded molecular architectures inspired by the structures and functions of biopolymers. This highlight focuses on important developments concerning foldamers produced by chemical synthesis and on the perspectives that these new self …

As one sets out to create synthetic foldamers, it is useful to identify general principles that govern the conforma-tions of the biofoldamers, proteins and RNA. Three principles seem to be particularly important: (i) hierarchi-cal organization of conformation (secondary structure vs tertiary structure); (ii) cooperativity in higher order struc-

2020年9月16日 · It covers topics ranging from foldamer design (new foldamers and their building blocks), applications (for example biology and medicinal chemistry), foldamers for bio- and nanomaterials, and catalysis.

2020年7月18日 · Regardless of the backbone type (peptidic or abiotic), the most important features of foldamers are the high stability, easy predictability and tunability of their folding, as well as the possibility to endow them with enhanced biological functions, with respect to their natural counterparts, by the correct choice of monomers.

2020年1月1日 · Foldamers are non-natural oligomers that mimic the structural behaviour of natural peptides, proteins and nucleotides by folding into a well-defined 3D conformation in solution. Since their first description about two decades ago, numerous studies have been undertaken dealing with the design, synthesis, characterization and application of ...

2017年6月29日 · Bio-inspired synthetic backbones leading to foldamers can provide effective biopolymer mimics with new and improved properties in a physiological environment, and in turn could serve as useful tools to study biology and lead to practical applications in the areas of diagnostics or therapeutics.

A foldamer is a biomimetic folding polymer that consists of sequence-specific oligomers similar to peptides, proteins, and oligonucleotides. It folds into well-defined three-dimensional structures with specific compact conformations. Research on foldamers is progressing rapidly.

2020年11月7日 · Foldamers are non-natural oligomers that mimic the structural behaviour of natural peptides, proteins and nucleotides by folding into a well-defined 3D conformation in solution. Since their first description about two decades ago, numerous studies have been undertaken dealing with the design, synthesis, characterization and application of ...