2024年12月25日 · FOSL1 (FOS Like 1, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with FOSL1 include Trichorhinophalangeal Syndrome, Type I and Colorectal Cancer. Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and IL-1 Family Signaling Pathways.

The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [6]

FOSL1 is a determinant of lung cancer in vivo and regulates tumor cell proliferation and survival, largely in the context of KRAS mutations through amphiregulin and cell survival gene regulation. Findings suggest that fos-related antigen 1 (Fra-1) transcription factor leads to the production of interleukin 11 (IL-11) protein in ulcerative ...

In solid tumors, FOSL1 controls the progression of tumor cells through the epithelial–mesenchymal transformation. In this review, we summarize the available data on FOSL1 expression, stabilization, and degradation in the cell.

2021年8月4日 · 在体外和体内模型中，利用构成型和诱导型短发夹RNA对人和小鼠胆管癌细胞系中的FOSL1进行遗传抑制。 使用胆管癌 (KRAS和Trp53突变敲除)基因工程小鼠 (GEM)模型进行条件性FOSL1消融。 后续进行RNA和染色质 免疫 沉淀 (ChIP)测序分析，并使用遗传和药理抑制验证下游靶点。 对胆管癌中FOSL1进行种间分析。 首先发现FOSL1在人和小鼠的胆管癌患者中高度上调，并与患者的低生存率相关。 胆管癌细胞中不同信号通路的药理学抑制集中在对FOSL1表达 …

2021年7月19日 · We demonstrated that FOSL1 directly regulates the four transcription factors binding their promoter regions, is involved in the deregulation of several stemness markers, and reduces the cells’...

Fos 基因家族由 4 个成员组成：FOS、FOSB、FOSL1 和 FOSL2。 这些基因编码的亮氨酸拉链蛋白可以与 JUN 家族的蛋白二聚化，从而形成转录因子复合物 AP-1。 因此，FOS 蛋白被认为是细胞增殖、分化和转化的调节剂。 已发现该基因编码不同亚型的几种转录变体。 [RefSeq 提供，2014 年 7 月] The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2.

FOSL1 is identified as a crucial controller of invasion and metastatic dissemination, making it a potential target for therapeutic treatment in cancer patients. The review offers a thorough examination of the regulatory systems that govern the influence exerted on FOSL1.

Fos基因家族由4个成员组成：FOS、FOSB、FOSL1和FOSL2。 这些基因编码可以与JUN家族蛋白质二聚化的亮氨酸拉链蛋白，从而形成转录因子复合物AP-1。 因此，FOS蛋白被认为可以调节细胞增殖、分化和转化。 已发现这个基因有几个编码不同异型的转录变异体。 [由RefSeq，2014年7月提供] 该模块正在开发中，请耐心等待我们的数据更新。 Dir./Indir. Human chromosome 11 DNA sequence and analysis including novel gene identification.

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including in utero embryonic development; placenta blood vessel development; and vitellogenesis.