Regulation of the master regulator FOXM1 in cancer - PMC
The transactivation domain (TAD) of FOXM1 can be suppressed by direct interaction with the NRD (N-terminal repression domain). To a transcription factor such as FOXM1, sufficient …
Targeting FOXM1 condensates reduces breast tumour growth and …
2025年1月15日 · FOXM1 is transcriptionally super-active towards oncogenic targets in a phase-separated state, and we revealed a mechanism for the role of FOXM1 LLPS-mediated FKH …
An order-to-disorder structural switch activates the FoxM1 ...
2019年5月28日 · We report the solution structure of an autoinhibited NRD-TAD complex within FoxM1, a critical activator of mitotic gene expression. We observe that while both the FoxM1 …
The conformation of FOXM1 homodimers - Oxford Academic
2024年11月13日 · To determine the minimal NRD sequence of human FOXM1 with inhibitory function, we conducted secondary structure prediction on the FOXM1 NRD sequences across …
FOXM1: An emerging master regulator of DNA damage response …
The FOXM1 protein consists of 3 functional regions, an N-terminal Repressor Domain (NRD), a Forkhead/Winged-helix domain (FKH) and a Transcativation Domain (TAD). The NRD is found …
Targeting the oncogenic transcription factor FOXM1 to improve …
2023年6月27日 · We discuss new inhibitors of FOXM1 and highlight FOXM1 as an attractive target for controlling drug-resistant and difficult-to-suppress breast cancers, and how blocking …
Dysregulated FOXM1 signaling in the regulation of cancer stem cells
2022年11月1日 · FOXM1 and the Vitamin D receptor (VDR) interact with β-catenin to control cellular processes and activate VDR signaling, which inhibits FOXM1 and its downstream …
RCSB PDB - 6OSW: An order-to-disorder structural switch …
Many transcription factors contain a negative regulatory domain (NRD) that suppresses recruitment of transcriptional machinery through autoregulation of the TAD. We report the …
An order-to-disorder structural switch activates the FoxM1 ...
We report the solution structure of an autoinhibited NRD-TAD complex within FoxM1, a critical activator of mitotic gene expression. We observe that while both the FoxM1 NRD and TAD are …
An order-to-disorder structural switch activates the FoxM1 ...
2019年5月28日 · Many transcription factors contain a negative regulatory domain (NRD) that suppresses recruitment of transcriptional machinery through autoregulation of the TAD. We …