CSCs with increased OXPHOS levels maintained low ROS levels by coupling FoxM1-dependent Prx3 expression and fatty acid oxidation-mediated NADPH regeneration. Thus, interventions …

2023年5月1日 · Effects of FOXM1 expression status on ROS regulation in OSCC cell lines. Representative images and quantitative analysis of the immunofluorescence of ROS/SOD …

2020年9月1日 · This study showed that CSCs exhibit increased OXPHOS and paradoxically maintain a low level of ROS, through coupling of FoxM1-dependent Prx3 expression and FAO …

Western blot analysis showed that increased ROS levels can activate FOXM1 expression and that inhibiting ROS generation significantly reduced the expression of FOXM1. These findings …

2023年8月24日 · FOXM1 promotes the synthesis of FAs by regulating the expression of relevant genes at the transcriptional level. Our study suggests that targeting of FOXM1 combined with …

It was found that FOXM1 regulates reactive oxygen species (ROS) levels in neutrophils, and the inhibition of FOXM1 leads to an increase in ROS, resulting in the formation of DFU. One study …

2024年11月1日 · To investigate the effects of FOXM1 on oxidative stress and mitochondrial function during oocyte aging, we assessed the levels of ROS, GSH, CAT, SOD, T-AOC, and …

2022年2月1日 · Mechanistically, the enzyme phospholipase D1 (PLD1) was identified as a potential effector target of FOXM1. PLD1 promoted LD accumulation, which reduced the level …

Over-expression of a constitutively active MKL1 in vascular smooth muscle cells enhanced proliferation in a ROS-dependent manner. On the contrary, MKL1 depletion or inhibition …

2021年11月5日 · Our data demonstrated that overexpression of NOX4, a producer of mitochondrial ROS that stabilizes HIF-1α, induced aerobic glycolysis by regulating FOXM1 …