Heterogeneity of FTLD syndromes and outcome measures: New approaches to measuring disease progression. FTLD encompasses an array of clinical syndromes involving behavior, speech and/or motor deficits that arise from a handful of similar underlying brain pathologies, most commonly FTLD-tau or FTLD-TDP [31, 32].

Common variants in the transmembrane protein 106 B were identified as a genetic risk factor of FTLD and disease modifier in patients with known mutations. This review summarizes for each FTLD gene what we know about the type and frequency of mutations, their associated clinical and pathological features, and potential disease mechanisms.

2023年8月10日 · Frontotemporal lobar degeneration (FTLD) is one of the most common causes of early-onset dementia and presents with early social–emotional–behavioural and/or language...

Frontotemporal lobar degeneration (FTLD) is a pathological process that occurs in frontotemporal dementia. It is characterized by atrophy in the frontal lobe and temporal lobe of the brain, with sparing of the parietal and occipital lobes. [1][2]

Frontotemporal lobar degeneration (FTLD) is a highly heterogenous group of progressive neurodegenerative disorders characterized by atrophy of prefrontal and anterior temporal cortices. Recently, the research in the field of FTLD has gained ...

Frontotemporal Lobar Degeneration (FTLD) refers to a clinically, pathologically and genetically heterogeneous group of disorders that affect principally the frontal and temporal lobes of the brain. After Alzheimer's disease, it is the second most common cause of dementia in …

2013年10月1日 · We propose an algorithm based on four criteria to help to pinpoint the genetic cause of FTLD: Presence of ALS in the patient or family; age at onset of FTLD; progranulin plasma level; and other disorders present in the patient or family.

2020年9月1日 · Frontotemporal lobar degeneration (FTLD) designates a spectrum of degenerative dementias with remarkable heterogeneity from a clinical, pathological and genetic point of view. FTLD is considered the second cause …

2018年5月18日 · Frontotemporal lobar degeneration (FTLD) defines a group of neurodegenerative brain disorders with predominant degeneration of the frontal and/or the...

This review summarizes for each FTLD gene what we know about the type and frequency of mutations, their associated clinical and pathological features, and potential disease mechanisms. We also provide an overview of emerging disease pathways encompassing multiple FTLD genes.