2024年12月25日 · KHSRP (KH-Type Splicing Regulatory Protein) is a Protein Coding gene. Diseases associated with KHSRP include Renal Cell Carcinoma With Mit Translocations and Pheochromocytoma. Among its related pathways are Cellular responses to stimuli and PERK regulates gene expression.

该项目进一步以核蛋白为切入点，采用两对肺癌高低转移细胞、两种蛋白质组学方法，结合小样本临床肺癌组织验证，筛选鉴定出远端上游元件结合蛋白2（fubp2）(又名kh型剪切调节蛋白，khsrp)作为肺癌转移相关候选蛋白。

2020年10月1日 · The combined loss of Fubp1 and Fubp2 (KOKD) yielded exaggerated and erratic MYC levels that even at steady state cracked the Stage I ceiling to express Stage II levels of MYC. Thus, the FUBPs ...

Of the multiple regions that reg-ulate MYC expression, we have been interested in the far upstream element (FUSE), which is 1.7 kb upstream of the major P2 transcription start site of human MYC...

2025年2月8日 · 本研究首次证实了 Fangchinoline 对结膜黑色素瘤的显著抑制作用，其机制主要通过直接结合 FUBP2 和抑制同源重组通路来实现。 此外，Fangchinoline 还能增加结膜黑色素瘤细胞对 DNA 损伤药物的敏感性，为结膜黑色素瘤的治疗提供了新的策略和潜在药物。

2021年4月7日 · FUBP2 is a multifunctional nucleic acid-binding protein belonging to the FUBP family. It plays an important role in cancer invasion and has been identified as a...

2017年9月13日 · FUBP1 and FUBP2 are both localized in cell nuclei, and are highly homologous; however, Fubp1 knockout mice are embryonically lethal with defects in multiple systems, especially hematopoiesis, while Fubp2 knockout mice are viable and fertile.

2020年10月1日 · Here, we study the variation of MYC amongst single primary cells (B-cells and murine embryonic fibroblasts, MEFs) for the repercussions of variable cellular MYC-levels and setpoints.

核蛋白fubp2对肺癌转移的影响及分子机制研究. 负责人：闫明霞. 依托单位：上海交通大学. 批准年份：2015

FUBP2, also called FUSE-binding protein 2, or KH type-splicing regulatory protein (KSRP), or p75, is a single-strand nucleic acid binding protein implicated in a variety of cellular processes, including splicing in the nucleus, mRNA decay, maturation of miRNA, and transcriptional control of proto-oncogenes such as c-myc.