2021年3月16日 · Our findings uncover the Xbp1s-FoxO1 axis as a pivotal mechanism in the pathogenesis of cardiometabolic HFpEF and unveil previously unrecognized mechanisms whereby the UPR governs metabolic...

2024年8月27日 · 巨噬细胞Foxo1缺失（Foxo1M-KO）改善了HFD肝脏中的肝炎、脂肪肝和纤维化，减少了HFD肝脏中STING（stimulator of IFN genes）、TBK1（TANK-binding kinase 1）和NF-κB的激活。 但Foxo1和YAP双基因敲除（Foxo1/YAPM-DKO）或Foxo1和Notch1双基因敲除（Foxo1/Notch1M-DKO）促进了STING功能，并加剧HFD诱导的肝损伤。 而Foxo1M-KO显著降低了棕榈酸（PA）和油酸（OA）刺激的Kupffer细胞释放的TGF-β1，并在与Kupffer细胞共培养 …

FOXO转录因子 家族通过调节基因表达参与细胞的生理事件，包括凋亡、细胞周期控制、葡萄糖代谢、氧化应激抵抗和寿命延长。 FOXO蛋白的一个核心调控机制是在胰岛素或多种生长因子刺激下，通过丝氨酸/苏氨酸激酶 Akt /蛋白激酶B (Akt/PKB)磷酸化，磷酸化发生在磷脂酰肌醇3-激酶 (PI3K)的下游。 在三个保守的位点上的磷酸化导致FOXO蛋白从细胞核转移到细胞质，从而降低了FOXO目标基因的表达。 相反，在氧化和营养应激刺激下，应激活化的c-JunN末端激酶 (JNK) …

2023年9月1日 · FOXO1 can regulate the lipogenesis by affecting the transcriptional activity of CD36 and STEAP4. Intramuscular fat content is closely related to the quality of beef, where the forkhead box protein O1 (FOXO1) is involved in adipocyte differentiation and lipid metabolism, but the specific mechanism of its involvement is still unclear.

2025年2月15日 · In this study, we investigated the role of FOXO1 in PFOS-induced glycolipid metabolism disorders. Our findings indicate that PFOS exposure increases hepatic Ac-FOXO1 expression, promotes liver lipid accumulation, and disrupts glucose homeostasis.

Forkhead box O1 (FoxO1) is involved in lipid metabolisms. However, its role in chronic stress-related nonalcoholic fatty liver disease (NAFLD) is unclear. The scientific premise of our study was based on the finding that FoxO1 expression is increased in …

FoxO1 Forkhead proteins are major targets of insulin action. The insulin signaling through FoxO1 plays an important role in regulating hepatic microsomal triglyceride transfer protein (MTP) expression and very low-density lipoprotein (VLDL) production (Zangerolamo et al., 2019).

2021年5月13日 · FoxO1是叉头转录家族O亚族的一类代谢性调节因子，通过磷酸化、乙酰化、泛素化修饰等方式调控多种基因的表达。FoxO1可以结合于PDX-1基因的启动子上，通过抑制其转录活性，抑制胰岛β细胞增殖、增加其去分化并促进其凋亡。

The expression of lncRNA enhancing endothelial nitric oxide synthase expression (LEENE), Forkhead box O1 (FoxO1) and ATP binding cassette transporter A1 (ABCA1) was evaluated by qRT-PCR and/or western blot. Lipid accumulation in macrophage was assessed by high-performance liquid chromatography and Oil red O staining.

2015年12月18日 · FoxO1 has emerged as a key player in insulin action and carbohydrate metabolism. FoxO1 targets PEPCK and G6Pase genes for trans-activation in the liver for regulating hepatic glucose production. Likewise, FoxO1 integrates insulin signaling to MTP in modulating VLDL-TG assembly and secretion.