【AmBeed聚焦】深入剖析JNK信号通路：作用原理及抑制剂研究
2024年5月27日 · JNK：MAPK超家族中的应激活化蛋白激酶及其生物学功能. JNK是促分裂原活化蛋白激酶(mitogen-activated protein kinase，MAPK)超家族成员之一。此外，由于JNK可被多 …
「AmBeed简析」JNK信号通路解析：机制、影响与抑制剂开发
JNK是促分裂原活化蛋白激酶(mitogen-activated protein kinase，MAPK)超家族成员之一。此外，由于JNK可被多种细胞外应激信号激活，其也被称为应激活化蛋白激酶(stress-activated …
Stress pathway outputs are encoded by pH-dependent clustering …
2024年8月5日 · Here we reveal that intracellular pH (pHi) is a significant component of the JNK network and defines signal response to specific stimuli. We show pHi regulates JNK activity in …
SAPK/JNK 信号级联放大 | Cell Signaling Technology
应激活化蛋白激酶 (sapk)/jun 氨基末端激酶 (jnk) 是 mapk 家族的成员，可由各种不同环境应激、炎症细胞因子、生长因子以及 gpcr 激动剂激活。 应激反应信号经 Rho 家族（Rac、Rho …
The JNK Signaling Pathway in Inflammatory Skin Disorders and …
JNK, also known as stress-activated protein kinases (SAPK), represents a subfamily of the canonical MAPK signal transduction pathway [1], which along with cyclin-dependent kinases …
G protein regulation of MAPK networks - PubMed
2007年5月14日 · G proteins provide signal-coupling mechanisms to heptahelical cell surface receptors and are critically involved in the regulation of different mitogen-activated protein …
The role of JNK signaling pathway in organ fibrosis
2024年10月2日 · JNK is involved in the TGF-β pathway, which plays an important part in cell activation, proliferation, and immune regulation. Evidence indicates that JNK can regulate the …
JNK signalling: a possible target to prevent neurodegeneration
JNK is an important transducing enzyme that is involved in many facets of cellular regulation including gene expression, cell proliferation and programmed cell death. The activation of JNK …
JNK pathway: diseases and therapeutic potential | Acta ... - Nature
2007年5月1日 · JNK are multifunctional kinases involved in many physiological processes. The JNK pathway has been shown to play a major role in apoptosis in many cell death paradigms …
c-Jun N-末端蛋白激酶 (JNK) 对 Bax 的调节是线粒体 ... - X-MOL
我们得出结论，无论 Bid 和 Bim 激活如何，Bax 的 JNK 依赖性调节对于介导细胞色素 c 的凋亡释放都是必不可少的。 JNK 影响线粒体的信号传导机制对于启动细胞凋亡至关重要。 在这里， …