2023年7月5日 · Increasing expression of P53, P21 and decreasing CCNB1, induction of cell G2/M cycle arrest, and consequently increase in the cell size can be suggested as one of the main mechanisms of...

2001年4月5日 · Repression of the topoisomerase II gene by p53 helps to block entry into mitosis and strengthens the G2 arrest. In summary, multiple overlapping p53-dependent and p53-independent pathways regulate the G2/M transition in response to genotoxic stress.

2021年12月9日 · To uncover the mechanism of Plk1-depletion-induced G2/M arrest in cancer cells and the critical role of p53, we developed a computational model by extending our recently developed model of...

2001年4月5日 · Repression of the topoisomerase II gene by p53 helps to block entry into mitosis and strengthens the G2 arrest. In summary, multiple overlapping p53-dependent and p53-independent pathways...

最近的数据显示，p53 调节的 WIP1 磷酸酶在癌症中对 DNA 损伤信号转导具有重要的阻断作用。研究人员发现在人体癌症中，p53 通常会发生突变，提示这个检查点是肿瘤形成的重要屏障。

2018年11月26日 · G2/M检查点，p53和肝癌. 细胞毒性的化疗对晚期癌症来说是最主要的治疗方法，并且化疗试剂会通过大量的DNA伤害trigger凋亡，这些损伤的DNA不能进行有效的DNA修复。我们也知道有些HCC展现出对化疗或放疗的抵抗。

When p53 is expressed at a level comparable to that induced by DNA damage in other cells, most MDAH041 cells arrested in G1, but a significant fraction also arrested in G2/M. Cells released from a mimosine block early in S phase stopped predominantly in G2/M in the presence of p53, confirming that p53 can mediate arrest at this stage, as well ...

Most of the 210 target genes are essential regulators of G 2 phase and mitosis. Thus, downregulation of these genes through the p53-p21-DREAM-CDE/CHR pathway appears to be a principal mechanism for G 2 /M cell cycle arrest by p53. The key functions of the tumor suppressor p53 are regulation of the cell cycle and induction of apoptosis.

PA-1, the only cell line found to express wild-type p53, showed the highest susceptibility to accumulate in G2/M and the strongest apoptotic response after irradiation. In this cell line irradiation resulted in an unequivocal accumulation of p53 protein and in …

2020年4月21日 · We found that G2 DNA damage suppressed SENP3 phosphorylation at G2/M phases in p53-dependent manner. We further found that the suppression of SENP3 phosphorylation was crucial for efficient...