GATA3 is a transcription factor that in humans is encoded by the GATA3 gene. Studies in animal models and humans indicate that it controls the expression of a wide range of biologically and clinically important genes.

A recent study found GATA-3 to be associated with favorable breast cancer pathologic features, including negative lymph node and positive estrogen receptor (ER) status. GATA-3 levels were also found to be an independent prognostic marker, with low expression predicting for breast cancer recurrence.

2024年12月25日 · GATA3 (GATA Binding Protein 3) is a Protein Coding gene. Diseases associated with GATA3 include Hypoparathyroidism, Sensorineural Deafness, And Renal Dysplasia Syndrome and Hypoparathyroidism-Deafness-Renal Disease Syndrome. Among its related pathways are Gene expression (Transcription) and ESR-mediated signaling.

GATA3是乳腺管腔上皮中表达最为广泛的转录因子，其功能在于维持其分化状态。 TCGA数据库 中的乳腺癌病例来说，GATA3是最常见突变的基因之一，可见于约10%的病例。 GATA3的功能突变型缺失与激素受体信号降低有关，因此和 上皮-间质转化 相关的基因会出现上调，促进肿瘤生长和浸润。 GATA3基因中第二个锌指结构域突变的患者预后更差；不过，任意GATA3突变的乳腺癌患者的总体预后都比较好，这说明有些GATA3突变是功能获得性，且可能会驱动管腔分化。 …

2024年12月2日 · While none of these markers alone is specific for breast carcinoma, most breast carcinomas are positive, particularly estrogen receptor (ER) positive tumors. The combined immunohistochemical findings in the other answer choices are most indicative of melanoma and carcinomas of urothelial and lung primary.

GATA3 is a useful marker in characterization not only mammary and urothelial but also for renal and germ cell tumors, mesotheliomas, and paragangliomas. The multiple specificities of GATA3 should be taken into account when using this marker …

GATA-binding protein 3 (GATA3) is a zinc-finger transcription factor that is continually expressed in a highly regulated manner throughout T-cell development and CD4 + T helper...

GATA3, a member of the GATA family of transcription factors, plays a vital role in regulating gene expression and key cellular processes, including differentiation, proliferation, and apoptosis. It is essential for the development and maintenance of various tissues and systems, including the immune, endocrine, and nervous systems [1, 2].

2024年2月20日 · 诊断尿路上皮癌：基底样<10%，管腔型60-75%（GATA3的表达在肿瘤内具有异质性）联合P63和S100，鉴别诊断尿路移行细胞起源的肿瘤以及未知来源的肿瘤. 2. 诊断乳腺癌和乳腺来源转移癌：浸润性导管癌（GATA3阳性率60-90%），三阴型乳腺癌（约40%），转移的情况下GATA3常仍有表达。 GATA3在乳腺癌中的表达和ER、PR正相关，HER-2负相关. 3. 鉴别诊断涎腺型肿瘤：100%表达：类似乳腺分泌性癌、涎腺导管癌、Warthin瘤和嗜酸细胞瘤；表达较 …

2000年5月24日 · gata3是一种在乳腺上皮、尿路上皮及t淋巴细胞亚型分化过程中起重要作用的转录因子。gata3在判断原发或转移性乳腺癌及尿路上皮癌的诊断中非常重要，但是其在其他正常组织及肿瘤组织中的表达至今还不明确。