GTP cyclohydrolase I - Wikipedia
GTP cyclohydrolase I (GTPCH) (EC 3.5.4.16) is a member of the GTP cyclohydrolase family of enzymes. GTPCH is part of the folate and biopterin biosynthesis pathways. It is responsible for …
Cell Metabolism 综述 | 铁死亡的代谢基础 - 知乎 - 知乎专栏
gch1 /bh4/dhfr系统. 近期一项研究通过crispr全基因组筛选并确定了一种不依赖于gpx4的铁死亡抑制基因，即鸟苷三磷酸环水解酶gch1（四氢生物蝶呤bh4合成的限速酶）。如果阻断二氢叶酸 …
GCH1 Gene - GeneCards | GCH1 Protein | GCH1 Antibody
2024年12月25日 · GCH1 (GTP Cyclohydrolase 1) is a Protein Coding gene. Diseases associated with GCH1 include Hyperphenylalaninemia, Bh4-Deficient, B and Dystonia, Dopa-Responsive. …
铁死亡十周年！66分的Cell再出重磅综述，我劝你赶紧收藏！ - 知乎
gch1或dhodh高表达的细胞表现出更强的铁死亡抵抗力，而低表达的细胞则对铁死亡更敏感。 最后，最近的一份研究表明，还有其他的铁死亡抑制机制，独立于 GSH/GPX4 …
GCH1 gene: MedlinePlus Genetics
More than 140 mutations in the GCH1 gene have been found to cause dopa-responsive dystonia. This condition is characterized by a pattern of involuntary muscle contractions (dystonia), …
GTP 环化水解酶 1（GCH1）基因 | MCE - MCE-生物活性分子大师
该基因的突变与恶性高苯丙氨酸血症和多巴反应性肌张力障碍有关。 已经描述了几种编码不同亚型的可变剪接转录物变体；然而，并非所有变体都会产生功能性酶。 [RefSeq 提供，2008 年 7 …
GCH1 Deficiency Activates Brain Innate Immune Response and …
2022年1月26日 · The Parkinson's disease (PD) risk gene GTP cyclohydrolase 1 (GCH1) catalyzes the rate-limiting step in tetrahydrobiopterin (BH4) synthesis, an essential cofactor in …
GTP cyclohydroxylase1 (GCH1): Role in neurodegenerative diseases
2023年12月20日 · GCH1 encodes the GTP cyclohydrolase 1 enzyme, which catalyzes the first step of tetrahydrobiopterin synthesis. Mutation in GCH1 causes various neurodegenerative …
2643 - Gene ResultGCH1 GTP cyclohydrolase 1 [ (human)]
GCH1 mutations induce the distinctive symptoms among young or middle age at onset. It is a genetic risk for Parkinson's disease. One novel mutation of c.679A>G (p.T227A) in GCH1 and …
GCH1 GTP cyclohydrolase 1 [ Homo sapiens (human) ]
2021年1月9日 · Microarray analysis indicates HIV-1 Tat-induced upregulation of GTP cyclohydrolase 1 (GCH1) in primary human brain microvascular endothelial cells: PubMed