Tetrahydrobiopterin metabolism attenuates ROS generation and ...
2024年5月1日 · Here, we showed that ionizing radiation disrupted the structural integrity of BH4 and downregulated GTP cyclohydrolase I (GCH1), which is the rate-limiting enzyme in BH4 …
Reduction of Neuropathic and Inflammatory Pain through …
2015年6月17日 · We therefore generated inducible sensory neuron-specific Gch1 KO mice to show that blocking BH4 production is sufficient to partially reverse established hypersensitivity, …
GCH1 Gene - GeneCards | GCH1 Protein | GCH1 Antibody
2024年12月25日 · GCH1 (GTP Cyclohydrolase 1) is a Protein Coding gene. Diseases associated with GCH1 include Hyperphenylalaninemia, Bh4-Deficient, B and Dystonia, Dopa-Responsive. …
Mechanisms underlying the efficacy and limitation of dopa and ...
2024年3月15日 · In this study, we tested the efficacy of dopa and BH4 therapies by using a novel GTPCH deficiency mouse model, Gch1KI/KI, which manifested infancy-onset motor deficits …
Cardiomyocyte tetrahydrobiopterin synthesis regulates fatty acid ...
2023年5月15日 · The cmGch1 KO mouse provides a new model to understand the cell‐ and tissue‐specific relationships between Gch1 expression, BH4 synthesis and BH4 recycling or …
Metabolic determinants of cancer cell sensitivity to canonical ...
2020年8月10日 · Guide resistant GCH1 (P30793–1) and SPR (P35270–1) cDNA was designed and codon-optimized. The truncated isoform, GCH1–3 (P30793–3), was amplified using …
Reduction of Neuropathic and Inflammatory Pain through …
2015年6月17日 · We therefore generated inducible sensory neuron-specific Gch1 KO mice to show that blocking BH4 production is sufficient to partially reverse established hypersensitivity, …
Identification of genes supporting cold resistance of mammalian …
2024年9月19日 · Gpx4 KO HapT1 cells exhibited a much faster accumulation of lipid peroxide than parental (wild type; WT) HapT1 cells, whereas both Gpx4 KO and WT HapT1 cells …
苏州大学曹建平/四川大学张舒羽揭示四氢生物蝶呤代谢调控放射性 …
2024年5月7日 · BH4是一氧化氮合（NOS）的重要辅助因子，由GTP经过限速酶GTP环化水解酶1（GTP cyclohydrolase 1，GCH1）等催化产生。 BH4在抗肿瘤方面发挥着重要的作用，2018 …
Cardiomyocyte tetrahydrobiopterin synthesis regulates fatty acid ...
2023年5月15日 · The cmGch1 KO mouse provides a new model to understand the cell- and tissue-specific relationships between Gch1 expression, BH4 synthesis and BH4 recycling or …