Interaction between the tRNA-Binding and C-Terminal Domains …
2015年2月19日 · The yeast Saccharomyces cerevisiae has a single eIF2α kinase, Gcn2, activated by uncharged tRNAs that accumulate in amino acid starved cells, which bind to a …
The HisRS-like domain of GCN2 is a pseudoenzyme that can bind …
2024年6月6日 · GCN2 is a stress response kinase that phosphorylates the translation initiation factor eIF2α to inhibit general protein synthesis when activated by uncharged tRNA and stalled …
The HisRS-like domain of GCN2 is a pseudoenzyme that can bind …
2024年6月6日 · The presence of a HisRS-like domain in GCN2, normally associated with tRNA aminoacylation, led to the hypothesis that eIF2α kinase activity is regulated by the direct …
Towards a model of GCN2 activation - PMC
GCN2 is capable of distinguishing between aminoacylated and deacylated tRNA species, and interactions between yeast GCN2 and deacylated tRNA have been demonstrated by both gel …
Multiple Roles of the Stress Sensor GCN2 in Immune Cells
General control nonderepressible 2 (GCN2), which is encoded by eukaryotic translation initiation factor 2 alpha (eIF-2α) kinase 4 (EIF2AK4), is a serine/threonine-protein kinase that senses …
General control nonderepressible 2 (GCN2) as a therapeutic target …
Overview of GCN2 protein domains and factors that activate GCN2. Active GCN2 phosphorylates the α subunit of eukaryotic translation initiation factor 2 which reduces global protein …
Activation of Gcn2 by small molecules designed to be inhibitors
2023年4月1日 · For recognition of these diverse stresses, Gcn2 has an amino-terminal RWD-protein interaction domain, pseudo kinase and protein kinase domains, a region related to the …
Cryo-EM structure of histidyl-tRNA synthetase-like domain reveals ...
2024年11月21日 · The molecular mechanism of GCN2 switching is not well understood due to the presence of a structurally and biochemically uncharacterized histidyl-tRNA synthetase-like …
Gcn2 structurally mimics and functionally repurposes the HisRS …
2024年8月20日 · We report crystal structures of the HisRS domain of Chaetomium thermophilum Gcn2 that reveal structural mimicry of both catalytic (CD) and anticodon-binding (ABD) …
GCN2 controls the cellular checkpoint: potential target for …
2018年2月14日 · GCN2, one of four known sensors of the ISR, can be activated by single amino acid deprivation. In the context of low levels of an amino acid, uncharged tRNA molecules …