Reciprocal regulation between GCN2 (eIF2AK4) and PERK
2020年9月15日 · To explore the potential mechanisms involved, we performed time-course drug treatment experiments on the parental MCF-7 and drug resistant MCF-7EpiR and MCF-7Tax …
GCN2 kinase Activation by ATP-competitive Kinase Inhibitors
We incubated recombinant GCN2 with uncharged tRNAs, neratinib, and a desthiobiotin-ATP probe, which biotinylates GCN2 when ATP has access to the kinase domain and then …
PERK and GCN2 Contribute to eIF2α Phosphorylation and Cell …
Our results demonstrate that PERK and GCN2 function to cooperatively regulate eIF2α phosphorylation and cyclin D1 translation after UPR activation. Integral membrane proteins …
eIF2α kinases GCN2 and PERK modulate transcription and …
2008年12月8日 · GCN2 was activated by deprivation of the essential amino acid Met, and PERK was activated with 2,5-di-tert-butylhydroquinone (tBuHQ), a selective inhibitor of ATP …
The coordinated action of VCP/p97 and GCN2 regulates cancer
2019年1月9日 · GCN2, an amino acid-sensing kinase, attenuated stress signalling and cell death triggered by VCP/p97 inhibition and nutrient shortages and modulated ERK activation, …
通过JNK-FOXO3轴在GCN2（eIF2AK4）和PERK（eIF2AK3）之间进 …
内质网（ER）应激调节剂PERK（eIF2AK3）的药物抑制剂已在联合疗法中显示出抗癌活性，但其作为单一药物的有效性受到限制，表明存在可能的代偿性细胞应答。 为了探索涉及的潜在机 …
Inhibition of GCN2 Reveals Synergy with Cell-Cycle Regulation and ...
2023年10月9日 · Previous studies have shown that GCN2 is a viable cancer target when amino acid stress is induced by inhibiting an additional target. In this light, we screened numerous …
Reciprocal regulation between GCN2 (eIF2AK4) and PERK (eIF2AK3 ... - PubMed
2020年9月15日 · Together these results demonstrate that GCN2 cooperates with PERK through the JNK-FOXO3 axis in a reciprocal negative feedback loop to mediate cancer …
eIF2 调控 | Cell Signaling Technology
此步骤必须受到密切调控，不同家族的 4 种应激激活的激酶 — pkr (dsrna)、perk（er 应激）、gcn2（氨基酸饥饿）和 hri（血红素不足）— 对 eif2α 的磷酸化后， eif2 可作为显性失活复合 …
GCN2 kinase activation by ATP-competitive kinase inhibitors
2021年12月23日 · A genome-wide CRISPR screen revealed that loss of general control nonderepressible 2 (GCN2) kinase increases cellular resistance to the pan-ErbB inhibitor …