The serine/threonine-protein kinase general control nonderepressible 2 (GCN2) is a well-known stress sensor that responds to amino acid starvation and other stresses, making it critical to the maintenance of cellular and organismal homeostasis.

2024年12月24日 · This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by …

In this review, we provide a brief overview of GCN2, including its structure, activation mechanisms and interacting partners, and explore its potential significance as a therapeutic target in various age-related diseases including neurodegeneration, inflammatory disorders and cancer.

Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability (PubMed: 25329545, PubMed: 32610081).

Two central signalling nodes that control cellular response to amino acid availability are the protein kinases mTOR and GCN2. In this review, we will discuss the current evidence for targeting GCN2 as a cancer therapeutic.

2021年12月23日 · A genome-wide CRISPR screen revealed that loss of general control nonderepressible 2 (GCN2) kinase increases cellular resistance to the pan-ErbB inhibitor neratinib with neratinib directly...

Showing 25 of 237 results for GCN2 Search Time: 0 ms in Aliases & Descriptions Drugs & Compounds Disorders Text-Mined Disorders Domains Expression in Human Tissues Function Genomics Localization Orthologs Paralogs Pathways Phenotypes Proteins Publications Summaries Transcripts Variants in category Protein Coding RNA Gene Functional Element ...

2025年2月8日 · Enables eukaryotic translation initiation factor 2alpha kinase activity and tRNA binding activity. Involved in intracellular signal transduction; positive regulation of cellular response to amino acid starvation; and regulation of translational initiation. Is …

2021年5月6日 · The Gcn2 kinase mediates cellular adaptations to amino acid limitation through the translational control of gene expression that is primarily executed by eIF2α phosphorylation. Here, Dokládal et al. show that Gcn2 targets auxiliary, physiologically relevant effectors, including eIF2β and Gcn20, to fine-tune translational control in response ...

To determine the potential role of GCN2 in the regulation of amino acid biosynthesis in higher eukaryotes, we have isolated the mouse Gcn2 gene and have generated a Gcn2 −/− knockout (loss-of-function) mutant mouse line.