The amino acid sensor GCN2 controls gut inflammation by
2016年3月16日 · General controlled non-repressed (GCN2) kinase is a key orchestrator of the ISR, and modulates protein synthesis in response to amino acid starvation. Here we …
Starving Intestinal Inflammation with the Amino Acid Sensor GCN2
2016年5月10日 · Indeed, mice fed a 2% low-protein diet or a leucine-deficient diet were protected from clinical symptoms of colitis and gut inflammation in a GCN2-dependent manner. Overall, …
General control nonderepressible 2 (GCN2) as a therapeutic target …
Tissue-specific knockdown of GCN2 in the gut and fat body, two energy-sensing organs in Drosophila which are counterparts of mammalian liver and adipose tissue, abolishes the …
权威PNAS新发现：氨基酸传感器GCN2通过调节肝巨噬细胞控制红 …
2023年9月20日 · GCN2是在所有真核生物中发现的最进化保守的eIF2AK，其功能是通过调节细胞类型特异性功能来调节生理和病理进程，包括代谢、免疫、癌症等。 与此同时一些证据表 …
GCN2 controls the cellular checkpoint: potential target for
2018年2月14日 · Following the activation of GCN2, a series of events occur that prevent gut inflammation 2. In addition to the phosphorylation of eIF2α by GCN2, other mechanisms …
The amino acid sensor GCN2 controls gut inflammation by ... - PubMed
2016年3月24日 · General controlled non-repressed (GCN2) kinase is a key orchestrator of the ISR, and modulates protein synthesis in response to amino acid starvation. Here we …
Starving Intestinal Inflammation with the Amino Acid Sensor GCN2
2016年5月10日 · In a recent paper, Ravindran et al. (2016) uncovered a novel mechanism by which an amino acid sensing pathway controls inflammation in the gut. Metabolic stressors are …
The amino acid sensor GCN2 controls gut inflammation by …
2016年3月3日 · General controlled nonrepressed (GCN2) kinase is a key orchestrator of the ISR, and modulates cellular metabolism in response to amino acid starvation. Here we demonstrate …
氨基酸传感器 GCN2 通过抑制炎症小体激活来控制肠道炎 …
2016年3月1日 · CD11c+ APC 或肠上皮细胞中 Gcn2（也称为 Eif2ka4）的基因缺失导致炎症体激活和白细胞介素 (IL)-1β 产生增强，从而导致肠道炎症和辅助 T 17 细胞 (TH17) 反应增强。
The amino acid sensor GCN2 controls gut inflammation by …
General controlled non-repressed (GCN2) kinase is a key orchestrator of the ISR, and modulates protein synthesis in response to amino acid starvation. Here we demonstrate in mice that …