eIF2α kinases GCN2 and PERK modulate transcription and …
2008年12月8日 · While there is only one known eIF2α kinase in yeast, general control nonderepressible 2 (GCN2), mammals have evolved to express at least four: GCN2, heme …
eIF2 调控 | Cell Signaling Technology
此步骤必须受到密切调控，不同家族的 4 种应激激活的激酶 — PKR (dsRNA)、PERK（ER 应激）、GCN2（氨基酸饥饿）和 HRI（血红素不足）— 对 eIF2α 的磷酸化后， eIF2 可作为显性 …
A MYC–GCN2–eIF2α negative feedback loop limits protein
2019年11月4日 · We therefore focused on EIF2AK2 (also known as PKR), which is activated by double-stranded RNA, and on EIF2AK4 (also known as GCN2), which is activated by …
Nature：线粒体可释放求救信号到细胞质中 - 知乎
eif2α磷酸化由四种激酶介导，即gcn2、perk、pkr和 hri 每个磷酸化的eif2α对不同的应激源有反应。氨基酸的减少刺激了绿色通道2；perk对一种叫做内质网的组织中未折叠蛋白质的存在作出 …
Integrated stress response of vertebrates is regulated by four …
2016年9月16日 · Four eIF2α kinases, namely heme-regulated inhibitor (HRI), protein kinase R (PKR), PKR-like endoplasmic reticulum kinase, (PERK) and general control non-depressible 2 …
Activation of the integrated stress response by inhibitors of its ...
2023年9月8日 · Reconstitution of ISR activation with recombinant proteins demonstrates that PERK and PKR inhibitors directly activate dimeric GCN2, following a Gaussian activation …
『珍藏版』Science综述 | 整合应激反应——从机制到复杂疾病 - 知乎
整合应激反应 （integrated stress response ISR）是蛋白质稳态失调时诱发的信号中心调控网络，主要以控制蛋白质合成速率来实现。 2020年4月24日，美国贝勒医学院的 Mauro Costa …
PKR and GCN2 Kinases and Guanine Nucleotide Exchange Factor …
Four stress-responsive protein kinases, including GCN2 and PKR, phosphorylate eukaryotic translation initiation factor 2α (eIF2α) on Ser51 to regulate general and gene-specific protein …
PKR and GCN2 stress kinases promote an ER stress-independent …
2018年5月31日 · Notably, we identified PKR and GCN2 as key mediators of eIF2α phosphorylation, facilitating the translocation of CTR on melanoma cells surface, under pro …
Mechanistic Link between PKR Dimerization, Autophosphorylation…
2005年9月23日 · The protein kinases PKR, HRI, PERK, and GCN2, which constitute a functional family called the eIF2α protein kinases, share a conserved kinase domain (KD); however, …