权威PNAS新发现：氨基酸传感器GCN2通过调节肝巨噬细胞控制红 …
2023年9月20日 · GCN2是在所有真核生物中发现的最进化保守的eIF2AK，其功能是通过调节细胞类型特异性功能来调节生理和病理进程，包括代谢、免疫、癌症等。 与此同时一些证据表 …
Multiple Roles of the Stress Sensor GCN2 in Immune Cells
General control nonderepressible 2 (GCN2), which is encoded by eukaryotic translation initiation factor 2 alpha (eIF-2α) kinase 4 (EIF2AK4), is a serine/threonine-protein kinase that senses …
The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination …
2023年12月5日 · Herein, we identify a novel amino-acid-sensing mechanism of mTORC1 that utilizes uncharged transfer RNA (tRNA)-mediated general control nonderepressible 2 (GCN2) …
GCN2 in Viral Defence and the Subversive Tactics ... - ScienceDirect
2024年7月1日 · Another mechanism of GCN2 activation is by viral RNA binding to the HisRS-like domain of GCN2 (Figure 3 c). Analogous to uncharged tRNAs binding to the HisRS-like …
GCN2 drives macrophage and MDSC function and ... - Science
To determine the cell-intrinsic role of GCN2 in myeloid function, we conducted in vitro experiments characterizing the transcriptome by RNA-seq and DNA binding characteristics of its obligate …
General control nonderepressible 2 (GCN2) as a therapeutic target …
The blocking of early viral SV RNA translation by GCN2 inhibits SV replication, pointing out another important function of GCN2 in the cellular response to viruses. Upon yellow fever …
A new role of GCN2 in the nucleolus - ScienceDirect
2017年4月1日 · General control nonderepressible 2 (GCN2) is activated by the accumulation of uncharged tRNA in response to amino acid shortage and regulates amino acid starvation …
The amino acid sensor GCN2 controls red blood cell clearance and …
GCN2 (general control nonderepressible 2) is a serine/threonine-protein kinase that controls messenger RNA translation in response to amino acid availability and ribosome stalling. Here, …
A new role of GCN2 in the nucleolus - PubMed
2017年4月1日 · Our findings reveal a role of GCN2 in the nucleolus that is involved in the expression of small RNA transcripts and serves as alternative stress-sensing machinery for …
The HisRS-like domain of GCN2 is a pseudoenzyme that can bind …
2024年6月6日 · GCN2 is a stress response kinase that phosphorylates the translation initiation factor eIF2α to inhibit general protein synthesis when activated by uncharged tRNA and stalled …