Gcn4 is a yeast transcriptional activator induced by amino acid starvation. ChIP-seq analysis revealed 546 genomic sites occupied by Gcn4 in starved cells, representing ~30% of Gcn4 …

In Saccharomyces cerevisiae, deletion of large ribosomal subunit protein-encoding genes increases the replicative lifespan in a Gcn4-dependent manner. However, how Gcn4, a key …

Gcn4, a basic leucine zipper protein, is the primary regulator of the transcriptional response to amino acid starvation (Hinnebusch and Fink, 1983). It is regulated at multiple levels, all of …

2017年9月6日 · Our data suggest that Gcn4 is a central regulator of protein synthesis under multiple perturbations, including ribosomal protein gene deletions, calorie restriction, and …

2020年12月30日 · By integrating matched transcriptome and ChIP-Seq analysis, we decipher genome-wide direct and indirect roles for Gcn4 in this growth program. Genes that enable …

Gcn4 is a transcription factor and a “master regulator” for gene expression which regulates close to one tenth of the yeast genome. In a study by Razaghi et al, [1] amino acid starvation …

2018年4月19日 · Gcn4 is a yeast transcriptional activator induced by amino acid starvation. ChIP-seq analysis revealed 546 genomic sites occupied by Gcn4 in starved cells, representing …

2018年4月19日 · Gcn4 is a yeast transcriptional activator induced by amino acid starvation. ChIP-seq analysis revealed 546 genomic sites occupied by Gcn4 in starved cells, representing …

Gcn4 是一种由氨基酸饥饿诱导的酵母转录激活剂。ChIP-seq 分析显示，在饥饿细胞中，Gcn4 占据了 546 个基因组位点，占 Gcn4 结合基序的 ∼30%。令人惊讶的是，只有 ∼40% 的结合位 …

By integrating matched transcriptome and ChIP-Seq analysis, we decipher genome-wide direct and indirect roles for Gcn4 in this growth program. Genes that enable metabolic precursor …