『珍藏版』Science综述 | 整合应激反应——从机制到复杂疾病 - 知乎
整合应激反应 （integrated stress response ISR）是蛋白质稳态失调时诱发的信号中心调控网络，主要以控制蛋白质合成速率来实现。 2020年4月24日，美国贝勒医学院的 Mauro Costa …
Multiprotein bridging factor 1 is required for robust activation of …
2024年11月19日 · The transcription factor Gcn4 is the key effector of the yeast ISR, while the highly conserved multiprotein bridging factor 1 (Mbf1; EDF1 in humans) was identified as a …
Multiprotein bridging factor 1 is required for robust ... - PubMed
2024年12月5日 · In yeast, multiprotein bridging factor 1 (Mbf1) has been proposed to function in the integrated stress response (ISR) as a transcriptional coactivator by mediating a direct …
Our biochemical and struc-tural analyses reveal that Mbf1 functions as a core ISR factor by interacting with collided ribosomes to mediate Gcn2 activation. We further show that Mbf1 …
eIF4F complex dynamics are important for the activation of the ...
2024年6月6日 · In response to stress, eukaryotes activate the integrated stress response (ISR) via phosphorylation of eIF2α to promote the translation of pro-survival effector genes, such as …
The integrated stress response: From mechanism to disease
2020年4月24日 · ISR-induced reduction in TC enables a portion of scanning ribosomes to initiate at the canonical AUG of the GCN4/ATF4 ORFs instead. Other uORF-containing mRNAs are …
The integrated stress response in metabolic adaptation - PMC
If there is a basal level of eIF2α kinase that produces a small amount of unstable GCN4, regulatory inputs that stabilize this transcription factor could effectively stimulate ISR signaling. …
Translational induction of ATF4 during integrated stress response ...
2020年9月16日 · ISR signaling is initiated by stress-activated kinases that phosphorylate the α-subunit of the eIF2 complex, thereby inhibiting eIF2’s ability to deliver initiator methionyl-tRNA …
eIF4E integrates into stress response - ScienceDirect
2024年6月6日 · Besides genes involving amino acid catabolism, Diamond et al. 1 observed upregulation of GCN4 in response to eIF4E depletion. As a transcription factor typically …
Contributions of Ccr4 and Gcn2 to the Translational Response of
2023年4月5日 · In addition to repressing cap-dependent translation initiation, Gcn2-mediated eIF2α phosphorylation in yeast simultaneously promotes the translation of the transcription …