2021年1月15日 · General control non-depressible 5 (GCN5) or lysine acetyltransferase 2A (KAT2A) is one of the most highly studied histone acetyltransferases. It acts as both histone acetyltransferase (HAT) and lysine acetyltransferase (KAT).

2024年12月25日 · KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009] See ...

在人类中有三个主要的HAT家族被充分研究，包括GNAT (HAT1, GCN5, PCAF)， MYST (Tip60, MOF,MOZ, MORF, HBO1)和p300/CBP。 不可避免的是，HATs也可以催化广泛的非组蛋白的乙酰化，包括肿瘤抑制子和癌基因，即 p53 、 Rb 和 Myc，以调节蛋白质稳定性、DNA结合、蛋白质相互作用、酶活性或蛋白质定位。 HATs催化乙酰基从乙酰辅酶a转移到组蛋白赖氨酸残基的氨基。 组蛋白尾部的乙酰化可以中和带正电荷的赖氨酸，这被认为可以破坏尾部和带负电荷的核小 …

GCN5 是第一个被发现的组蛋白乙酰化酶，它以多亚基蛋白复合体的形式发挥功能，参与基因的转录激活（Brownell et al., 1996）。 真核生物中已发现的包含GCN5的蛋白复合体包括：物种间保守的SAGA复合体、酵母特异的 ADA复合体 、后生动物特异的 ATAC复合体 (Grant et al ...

2025年3月4日 · The acetyltransferase GCN5 is implicated in various diseases involving inflammation in peripheral tissues. Cho et al. found that GCN5 mediates inflammation in the brain as well, suggesting that it may be a target for treating neuroinflammatory diseases. In mice, inducing an innate immune response in the periphery (to mimic an infection) selectively increased the abundance of GCN5 in microglia ...

6 天之前 · The GCN5-dependent comparative transcriptomic analysis between C. auris and C. albicans showed that pathways such as sphingolipid metabolism and GPI anchor biosynthesis are significantly enriched in both species in a GCN5-dependent manner , suggesting a degree of conservation at the level of transcription in both species.

在这篇综述中，我们讨论了结构特征，GCN5 的生物学功能以及与其不平衡相关疾病的机械联系。 此外，将从药物化学的角度介绍目前的 GCN5 调节剂及其局限性。 一般控制不可抑制 5 (GCN5) 或赖氨酸乙酰转移酶 2A (KAT2A) 是研究最多的组蛋白乙酰转移酶之一。 它同时充当组蛋白乙酰转移酶 (HAT) 和赖氨酸乙酰转移酶 (KAT)。 作为 HAT，它在表观遗传景观和染色质修饰中发挥着关键作用。 此外，GCN5 调节范围广泛的生物事件，如基因调控、细胞增殖、代谢和炎症。 …

2020年9月1日 · Gcn5 indirectly regulate the expression of 114 genes by promoting the transcription of SET1. Many chromatin modifying factors regulate gene expression in an as-yet-unknown indirect manner. Revealing the molecular basis for this indirect gene regulation will help understand their precise roles in gene regulation and associated biological processes.

2025年3月8日 · GCN5 is highly expressed in high-grade gliomas. To identify significant molecular markers for the malignant evolution of gliomas, we analyzed clinical information and transcript expression data ...

6 天之前 · Here, we show that C. auris GCN5 lysine acetyltransferase is essential for cell wall remodeling, antifungal drug resistance, and virulence. The Candida albicans GCN5 has previously been shown to be an important regulator of antifungal drug resistance and virulence. Therefore, to identify Gcn5-dependent evolutionary conserved as well as ...