Growth/differentiation factor 5 is a protein that in humans is encoded by the GDF5 gene. [5] [6] [7] The protein encoded by this gene is closely related to the bone morphogenetic protein (BMP) family and is a member of the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved ...

2024年12月25日 · GDF5 (Growth Differentiation Factor 5) is a Protein Coding gene. Diseases associated with GDF5 include Brachydactyly, Type C and Brachydactyly, Type A2. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

GDF-5 is essential for cartilage development and homeostasis, and GDF-5 deficiency is associated with osteoarthritis (OA). Specifically, GDF-5 has high binding affinity to BMPR-IB, BMPR-II and Activin type II receptors. Upon binding to the receptors, the signalling cascade of GDF-5 activates the downstream Smad pathway.

Here, we present structural insights into the GDF-5:BMPR-IB complex revealing how binding specificity for BMPR-IB is generated on a molecular level. gene growth differentiate factor 5 is important in the aetiology of congenital dysplasia of the hip.

2021年2月1日 · Growth differentiation factor 5 (GDF-5) is essential for cartilage development and homeostasis. The expression and function of GDF-5 are highly associated with the pathogenesis of osteoarthritis (OA). OA, characterized by progressive degeneration of joint, particularly in cartilage, causes severe social burden.

2022年5月27日 · gdf-5与其受体bmpr-i/bmpr-ii结合，激活smad1/5/8、pi3k/akt、p38-mapk等信号，发挥促进细胞增殖分化、减少氧化应激损伤、细胞凋亡和组织纤维化等生物学功能。目前针对gdf-5的研究多聚焦在骨、软骨与肌腱的生长和修复等方面，而在其他器官中的生物学作用鲜有报道。

GDF-5 蛋白在骨和软骨形成中至关重要，通过双重途径复杂地调节软骨形成组织分化。它通过与 BMPR1B 和 BMPR1A 结合诱导 SMAD 蛋白信号传导，对软骨形成产生积极影响。GDF-5 蛋白, Human 是重组的 GDF-5 蛋白，由 E. coli 表达，不带标签。GDF-5 蛋白, Human 全长 120 个氨基 …

2025年1月4日 · GDF5 single-nucleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women. Williams FM, et al. Arthritis Rheum, 2011 Mar. PMID 21360499, Free PMC Article. A genetic association study between growth differentiation factor 5 (GDF 5) polymorphism and knee osteoarthritis in Thai population.

生长分化因子 5： 该基因编码 tgf-β (转化生长因子-β) 蛋白质超家族的分泌配体。 该家族的配体结合各种 TGF-β 受体，导致调节基因表达的 SMAD 家族转录因子的募集和激活。

2010年2月12日 · GDF-5是骨形态发生蛋白家族中较新的成员,在促进肢体发育,调节细胞分化,骨与软骨发育等方面具有重要的作用。 本文从其对肢体发育、软骨、骨等的影响方面进行综述。 GDF-5是骨形态发生蛋白家族中较新的成员,在促进肢体发育,调节细胞分化,骨与软骨发育等方面具有重要的作用。 本文从其对肢体发育、软骨、骨等的影响方面进行综述。