鸟苷二磷酸解离促进因子 - 百度百科
可将小G蛋白Rab上的鸟苷二磷酸解离抑制因子(GDI)置换的一种蛋白质。 当膜转运发生时，GDF将GDI从Rab上换掉后，使Rab从细胞质中回到膜上，与鸟苷酸交换因子(GEF)相互作用，GEF …
Identification of a GDI displacement factor that releases endosomal …
We report here the identification of a novel, membrane‐associated protein factor that can release prenylated Rab proteins from GDI. This GDI‐displacement factor (GDF) is not a guanine …
A GDI/GDF-like system for sorting and shuttling ciliary proteins
Rab and Rho are small G proteins which are prenylated and targeted to membranes in complex with solubilizing factors called guanosine dissociation inhibitors (GDIs). The release of Rab …
“Getting It On”—GDI Displacement and Small GTPase
2003年11月1日 · Membrane recruitment is initiated by the GDF, a membrane protein that displaces Rab-GDI from the cytosolic heterodimer with prenylated Rab. This is followed by …
A Bifunctional Bacterial Protein Links GDI Displacement to Rab1 ...
2007年11月9日 · It is believed that specialized proteins are required to displace GDI from Rab GTPases before Rab activation by guanosine diphosphate–guanosine 5′-triphosphate (GDP …
GDIs: central regulatory molecules in Rho GTPase activation
2005年7月1日 · In resting cells, Rho GTPase–GDI complexes are cytosolic and non-interactive. In response to cell stimulation, Rho GTPases are induced to dissociate from GDI through the …
Yip3 catalyses the dissociation of endosomal Rab–GDI complexes
2003年10月23日 · However, a GDI-displacement factor (GDF) facilitates the generation of free Rab9, which can then exchange bound GDP for 35 S-GTPγS (Fig. 1b) 10. This method can …
Purification and Properties of Yip3/PRA1 as a Rab GDI …
2005年1月1日 · The components of the GDF reaction are the Rab–GDI substrate, a test GDF sample or purified Yip3, and radiolabeled GTPγS. Rab–GDI complexes are produced using …
GEF，GAP和GDI对Rab活性的分子控制。,Small GTPases - X-MOL
此外，它们可以通过C末端的异戊二烯基半胱氨酸残基与膜结合，并且可以通过称为GDP离解抑制剂（GDI）的分子伴侣样分子溶解并在膜之间穿梭。 在这篇综述中，我们概述了Rab蛋白，重 …
Rab and Rho are small G proteins which are prenylated and targeted to membranes in complex with solubilizing factors called guanosine dissociation inhibitors (GDIs). The release of Rab …