胶质细胞源性神经营养因子 (glial cell derived neurotrophie factor，GDNF)是由Lin等 (1993)从鼠胶质细胞株B49的条件培养基中分离纯化获得的一种神经营养因子，且由此而命名。 以纯化的GDNF的氨基端序列制作探针，克隆得到大鼠和人的GDNF基因。 人GDNF前体蛋白为211个 氨基酸残基 (其中信号肽19个氨基酸)，加工处理后才形成分泌型的成熟蛋白，有134个氨基酸，是一个糖基化的二硫键连结的 同源二聚体 蛋白质，分子量为32~34kD，为 碱性蛋白质。 1996年， …

Glial cell line-derived neurotrophic factor (GDNF) is a protein that, in humans, is encoded by the GDNF gene. [5] GDNF is a small protein that potently promotes the survival of many types of neurons. [6] It signals through GFRα receptors, particularly GFRα1.

2024年12月25日 · GDNF (Glial Cell Derived Neurotrophic Factor) is a Protein Coding gene. Diseases associated with GDNF include Hirschsprung Disease 3 and Congenital Central Hypoventilation Syndrome. Among its related pathways are MAPK family signaling cascades and Kidney development.

GDNF抗体（B-8）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过多种应用检测小鼠、大鼠和人类样本中的胶质细胞系衍生神经营养因子（GDNF），包括蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、免疫组织化学和酶联免疫吸附测定（ELISA）。

Four different glial cell line-derived neurotrophic factor (GDNF)-family ligand (GFL)– receptor (GFRα) binding pairs exist, and they all signal through the transmembrane RET receptor tyrosine...

In a healthy adult brain, glial cell line-derived neurotrophic factor (GDNF) is exclusively expressed by neurons, and, in some instances, it has also been shown to derive from a single neuronal subpopulation. Secreted GDNF acts in a paracrine ...

Antibodies that detect GDNF can be used in several scientific applications, including Western Blot, Immunohistochemistry, ELISA, Immunocytochemistry and Flow Cytometry. These antibodies target GDNF in Human, Mouse, Rat, Bovine and Rabbit samples.

GDNF Promotes Astrocyte Abnormal Proliferation and Migration Through the GFRalpha1/RET/MAPK/pCREB/LOXL2 Signaling Axis. GDNF regulates lipid metabolism and glioma growth through RET/ERK/HIF1/SREBP1. Serum Glial Cell Line-Derived Neurotrophic Factor (sGDNF) Is a Novel Biomarker in Predicting Cirrhosis in Patients with Chronic Hepatitis B.

Glial-cell-line-derived neurotrophic factor (GDNF) 是一种属于 GDNF 家族配体 (GFL) 的神经营养因子，可促进多巴胺神经元的存活。 GDNF 对哺乳动物神经元表现出多种神经保护作用。

2024年6月11日 · 胶质细胞源性神经营养因子（Glial cell line-derived neurotrophic factor, GDNF）是一种神经营养因子，最初在培养的B49胶质瘤细胞系中发现。 GDNF在神经系统的发育、保护和修复过程中起着重要作用，尤其在多巴胺能神经元的存活和功能维持中具有关键作用。 2. **结构和信号传导** GDNF属于转化生长因子-β（TGF-β）超家族，其生物活性形式为同源二聚体。 GDNF通过与其受体GFRα1（GDNF Family Receptor alpha-1）结合，并与RET酪氨酸激 …